ArticleProtein and peptide letters2023
The Residual Structure of Unfolded Proteins was Elucidated from the Standard Deviation of NMR Intensity Differences.
Article in Protein and peptide letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionSensitive methods are necessary to identify the residual structure in an unfolded protein, which may be similar to the functionally native structure. Signal intensity in NMR experiments is useful for analyzing the line width for a dynamic structure; however, another contribution is contained.
methodsHere, the signal-intensity difference along the sequence was used for probability to calculate the standard deviation.
resultsThe relative values of the standard deviations were 0.57, 0.57, and 0.66 for alpha-synuclein wild-type, A53T, and A30P, respectively. This revealed that the flexible region was mainly in the Cterminal region of alpha-synuclein at higher temperatures as observed by the amide-proton exchange studies.
conclusionIn particular, the flexible structure was induced by the A30P mutation.
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