Evidence map›Paper›PMID 36600490›Full record

ArticleNeurogastroenterology and motility2023

History of trying exclusion diets and association with avoidant/restrictive food intake disorder in neurogastroenterology patients: A retrospective chart review.

Micaela Atkins, Claire Zar-Kessler, Elizabeth N Madva, Kyle Staller, Kamryn T Eddy, Jennifer J Thomas, Braden Kuo, Helen Burton Murray

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Neurogastroenterology and motility, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07000227 (Mechanism of FODMAP Restriction on Gut Microbiota and Gut Barrier Function in Functional Gastrointestinal Disorder Patients), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07000227 narecruitingnot on this mapstarted 2025, after this paper: background citation

Mechanism of FODMAP Restriction on Gut Microbiota and Gut Barrier Function in Functional Gastrointestinal Disorder Patients : A Randomised Controlled Trial

TypeinterventionalSponsorUniversiti Kebangsaan Malaysia Medical CentreRan2025 to 2026Enrolled60ConditionsFunctional Gastrointestinal Disorders (FGIDs), Irritable Bowel Syndrome (IBS), Functional DyspepsiaArmsLow FODMAP diet, Gentle FODMAP diet, Traditional Dietary Advice
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Guideline
  2. Avoidant-Restrictive Food Intake Disorder in Patients With Gastrointestinal Disorders: A Systematic Review.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Pooled it
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  19. Avoidant/Restrictive Food Intake Disorder: Review and Recent Advances.Focus (American Psychiatric Publishing) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Micaela AtkinsCenter for Neurointestinal Health, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-7951-4594
Claire Zar-KesslerCenter for Neurointestinal Health, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Elizabeth N MadvaCenter for Neurointestinal Health, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0003-2194-2032
Kyle StallerCenter for Neurointestinal Health, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0003-4925-4290
Kamryn T EddyHarvard Medical School, Boston, Massachusetts, USA.
Jennifer J ThomasHarvard Medical School, Boston, Massachusetts, USA.
Braden KuoCenter for Neurointestinal Health, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-7228-7317
Helen Burton MurrayCenter for Neurointestinal Health, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0003-2059-3256
Harvard University · US

Funding

A Biobehavioral Approach to Understand Problematic Avoidant/Restrictive Eating in Adults with Functional DyspepsiaK23DK131334 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BURTON MURRAY, HELEN · 2021 to 2025
$1.1M
The Role of Fiber in the Etiopathogenesis of Fecal IncontinenceK23DK120945 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI STALLER, KYLE · 2020 to 2024
$1.0M
NIDDK NIH HHS K23 DK120945NIDDK NIH HHS K23 DK131334
6 · The paper itself

Abstract

backgroundExclusion diets for gastrointestinal symptom management have been hypothesized to be a risk factor for avoidant/restrictive food intake disorder (ARFID; a non-body image-based eating disorder). In a retrospective study of pediatric and adult neurogastroenterology patients, we aimed to (1) identify the prevalence and characteristics of an exclusion diet history and (2) evaluate if an exclusion diet history was concurrently associated with the presence of ARFID symptoms.

methodsWe conducted a chart review of 539 consecutive referrals (ages 6-90, 69% female) to adult (n = 410; January-December 2016) and pediatric (n = 129; January 2016-December 2018) neurogastroenterology clinics. Masked coders (n = 4) retrospectively applied DSM-5 criteria for ARFID and a separate coder assessed documentation of exclusion diet history. We excluded patients with no documentation of diet in the chart (n = 35) or who were not orally fed (n = 9).

resultsOf 495 patients included, 194 (39%) had an exclusion diet history, and 118 (24%) had symptoms of ARFID. Of reported diets, dairy-free was the most frequent (45%), followed by gluten-free (36%). Where documented, exclusion diets were self-initiated by patients/parents in 66% of cases, and recommended by gastroenterology providers in 30%. Exclusion diet history was significantly associated with the presence of ARFID symptoms (OR = 3.12[95% CI 1.92-5.14], p < 0.001).

conclusionsHistory of following an exclusion diet was common and was most often patient-initiated among pediatric and adult neurogastroenterology patients. As patients with self-reported exclusion diet history were over three times as likely to have ARFID symptoms, providers should be cognizant of this potential association when considering dietary interventions.

Indexed as

Avoidant Restrictive Food Intake DisorderFeeding and Eating DisordersAdolescentAdultAgedAged, 80 and overChildEatingFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsYoung Adultavoidant/restrictive food intake disorderdisorders of gut-brain interactionfeeding and eating disordersfunctional gastrointestinal disorders

Identifiers

PMID36600490
PMCPMC11262773
OpenAlexW4313545109

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.