SynthesisArchives of disease in childhood. Fetal and neonatal edition2023
Thresholds for surfactant use in preterm neonates: a network meta-analysis.
Synthesis in Archives of disease in childhood. Fetal and neonatal edition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Surfactant therapy guided by tests for lung maturity in preterm infants at risk of respiratory distress syndrome.The Cochrane database of systematic reviews · 2023Pooled it
- Higher (40%) versus lower (30%) FiOEuropean journal of pediatrics · 2025Trial
- Surfactant use and outcomes in middle-income versus high-income countries.Journal of tropical pediatrics · 2026Article
- Prophylactic surfactant therapy in the era of less invasive surfactant delivery.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Lung ultrasound for predicting surfactant administration in ventilated and non-ventilated infants with respiratory distress syndrome: a multicenter prospective study.European journal of pediatrics · 2025Observational
- Comparison of Clinical Outcomes Between Calfactant and Poractant-Alfa in Preterm Infants with Respiratory Distress Syndrome.Children (Basel, Switzerland) · 2025Article
- Predicting Surfactant Need at Birth: Failed Validation of a Bedside Method Using Gastric Aspirates.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Less Invasive Surfactant Administration Versus Intubate-Surfactant-Extubate: Associated With Reduced Mechanical Ventilation in Extremely Preterm Infants.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Using a simplified Downes score to predict the receipt of surfactant in a highly resourced setting.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Lung Ultrasound Score for Prediction of Surfactant Administration in Preterm Infants with Respiratory Failure.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Neonatal point-of-care lung ultrasound: what should be known and done out of the NICU?European journal of pediatrics · 2024Review
- Clinical decision thresholds for surfactant administration in preterm infants: a systematic review and network meta-analysis.EClinicalMedicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo perform a network meta-analysis of randomised controlled trials of different surfactant treatment strategies for respiratory distress syndrome (RDS) to assess if a certain fraction of inspired oxygen (FiO
designSystematic review and network meta-analysis using Bayesian analysis of randomised trials of prophylactic versus selective surfactant for RDS.
settingCochrane Central Register of Controlled Trials, MEDLINE, Embase and Science Citation Index Expanded. PATIENTS: Randomised trials including infants under 32 weeks of gestational age.
interventionsIntratracheal surfactant, irrespective of type or dose.
main outcome measuresOur primary outcome was neonatal mortality, compared between groups treated with selective surfactant therapy at different thresholds of FiO
resultsOf 4643 identified references, 14 studies involving 5298 participants were included. We found no statistically significant differences between 30%, 40% and 50% FiO
conclusionOur results do not show a clear benefit of surfactant treatment at any threshold of FiO PROSPERO REGISTRATION NUMBER: CRD42020166620.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.