Evidence map›Paper›PMID 36600459›Full record

ArticlePediatric blood & cancer2023

Maternal anemia and the risk of childhood cancer: A population-based cohort study in Taiwan.

Helen T Orimoloye, Naveen Qureshi, Pei-Chen Lee, Chia-Kai Wu, Chai Saechao, Noah Federman, Chung-Yi Li, Beate Ritz, Onyebuchi A Arah, Julia E Heck

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric blood & cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Relationship between hemoglobin and lung cancer: evidence from Mendelian randomization and National Health and Nutrition Examination Survey.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Helen T OrimoloyeDepartment of Rehabilitation and Health Services, College of Health and Public Service, University of North Texas, Denton, Texas, USA.ORCID 0000-0002-3895-3363
Naveen QureshiDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York City, New York, USA.
Pei-Chen LeeDepartment of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chia-Kai WuDepartment of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chai SaechaoUCLA Health, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Noah FedermanDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, California, USA.ORCID 0000-0002-2627-6772
Chung-Yi LiDepartment of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID 0000-0002-0321-8908
Beate RitzDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Onyebuchi A ArahDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Julia E HeckDepartment of Rehabilitation and Health Services, College of Health and Public Service, University of North Texas, Denton, Texas, USA.ORCID 0000-0001-8713-8413
University of California, Los Angeles · USUniversity of North Texas · USChina Medical University · TWCity University of New York · USInserm · FRNational Cheng Kung University · TW

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Scientific and Technical CoreP2CHD041022 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Martha Jane Bailey · 2016 to 2026
$6.9M
NCATS NIH HHS UL1 TR001881NICHD NIH HHS P2C HD041022
6 · The paper itself

Abstract

backgroundChildhood cancer may be related to maternal health in pregnancy. Maternal anemia is a common condition in pregnancy, especially in low-income countries, but the association between maternal anemia and childhood cancer has not been widely studied.

objectiveTo examine the potential relation between maternal anemia during pregnancy and childhood cancers in a population-based cohort study in Taiwan.

methodsWe examined the relationship between maternal anemia and childhood cancer in Taiwan (N = 2160 cancer cases, 2,076,877 noncases). Cases were taken from the National Cancer Registry, and noncases were selected from birth records. Using national health registries, we obtained maternal anemia diagnoses. We estimated the risks for childhood cancers using Cox proportional hazard analysis.

resultsThere was an increased risk of cancers in children born to mothers with nutritional anemia (hazard ratio (HR): 1.32, 95% CI 0.99, 1.76). Iron deficiency anemia (HR: 1.30, 95% CI 0.97-1.75) carried an increased risk, while non-nutritional anemias were not associated with childhood cancer risk.

conclusionOur results provide additional support for screening for anemia during pregnancy. Adequate nutrition and vitamin supplementation may help to prevent some childhood cancer.

Indexed as

AnemiaNeoplasmsChildCohort StudiesDietary SupplementsFemaleHumansPregnancyTaiwananemiachildhood cancerfolic acidiron deficiencyneoplasmspregnancyvitamin B12

Identifiers

PMID36600459
PMCPMC10773261
OpenAlexW4313545967

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.