Evidence map›Paper›PMID 36600429›Full record

ArticleBMJ open2022

Characteristics of HIV pre-exposure prophylaxis users at first PrEP counselling visit: the CSL-PrEP cohort.

Silvia Nozza, Angelo Roberto Raccagni, Riccardo Lolatto, Daniele Ceccarelli, Laura Galli, Francesca Alberton, Elena Bruzzesi, Diana Canetti, Martina Strano, Marco Ripa and 2 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Silvia NozzaInfectious Diseases Unit, San Raffaele Hospital, Milano, Italy nozza.silvia@hsr.it.ORCID 0000-0002-2673-2731
Angelo Roberto RaccagniInfectious Diseases Unit, Vita-Salute San Raffaele University, Milano, Italy.ORCID 0000-0001-7811-6255
Riccardo LolattoInfectious Diseases Unit, San Raffaele Hospital, Milano, Italy.
Daniele CeccarelliInfectious Diseases Unit, San Raffaele Hospital, Milano, Italy.
Laura GalliInfectious Diseases Unit, San Raffaele Hospital, Milano, Italy.
Francesca AlbertonInfectious Diseases Unit, Vita-Salute San Raffaele University, Milano, Italy.
Elena BruzzesiInfectious Diseases Unit, Vita-Salute San Raffaele University, Milano, Italy.
Diana CanettiInfectious Diseases Unit, San Raffaele Hospital, Milano, Italy.
Martina StranoInfectious Diseases Unit, Vita-Salute San Raffaele University, Milano, Italy.
Marco RipaInfectious Diseases Unit, San Raffaele Hospital, Milano, Italy.
Costanza BertoniInfectious Diseases Unit, Vita-Salute San Raffaele University, Milano, Italy.
Antonella CastagnaInfectious Diseases Unit, San Raffaele Hospital, Milano, Italy.
Vita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPre-exposure prophylaxis (PrEP) is effective for HIV prevention and is mostly used by men who have sex with men (MSM). The aim of this study was to describe the characteristics of a cohort of PrEP users at first PrEP counselling visits (baseline, BL).

designCross-sectional study of a cohort of MSM receiving PrEP (Centro San Luigi, CSL-PrEP Cohort).

settingSecondary-level sexually transmitted infections (STI) centre in Milan, Italy, from May 2017 to May 2022.

participantsOverall, 624 MSM PrEP users were included; most users were Caucasian (97%), attended university (64%), with a median BL age of 34.5 years.

resultsOverall, 45% choose the daily-based PrEP regimen, 55% the event-based one. An increasing trend in PrEP counselling visits was observed (p=0.024). The majority had between 10 and 19 partners in the 3 months before BL and 41% were chemsex users. All had a HIV Incidence Risk Index for MSM (HIRI-MSM)>10, 54% between 20 and 29. Overall, 50% had ≥1 previous STI and 22% ≥1 BL STI. BL chlamydia (10%) was often more frequent than in the past (7%). The number of sexual partners was associated with BL chlamydia (p<0.001), gonorrhoea (p=0.002) and syphilis (p=<0.001), HIRI-MSM with chlamydia (p=0.001) and gonorrhoea (p=0.008), chemsex use with chlamydia (p=0.003) and gonorrhoea (p=0.030).

conclusionsWe observed an unbalanced access to PrEP in respect to all key populations which might benefit from PrEP, with a similar choice for event-based or daily-based regimens. High-risk behaviours and STIs were frequently observed. History of chlamydia was very frequently high in asymptomatic MSM at BL, compared with what observed before access to PrEP. High-risk behaviours and HIRI-MSM were associated with most of STIs.

Indexed as

ChlamydiaGonorrheaHIV InfectionsPre-Exposure ProphylaxisSexual and Gender MinoritiesSexually Transmitted DiseasesAdultCounselingCross-Sectional StudiesHomosexuality, MaleHumansMaleHIV & AIDSPREVENTIVE MEDICINESEXUAL MEDICINE

Identifiers

PMID36600429
PMCPMC9772673
OpenAlexW4312037063

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.