Evidence map›Paper›PMID 36600388›Full record

ArticleBMJ open2022

Rationale and design of leveraging the HIV platform for hypertension control in Africa: protocol of a cluster-randomised controlled trial in Uganda.

Mucunguzi Atukunda, Jane Kabami, Gerald Mutungi, Brian Twinamatsiko, Joan Nangendo, Starley B Shade, Edwin Charlebois, Heiner Grosskurth, Moses Kamya, Emmy Okello

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04624061 (Leveraging the HIV Platform for Hypertension Control in Uganda), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04624061 naunknown statusnot on this map

Leveraging the HIV Platform for Hypertension Control in Uganda

TypeinterventionalSponsorInfectious Diseases Research Collaboration, UgandaRan2020 to 2024Enrolled2,600ConditionsHIV, HypertensionArmsIntegrated HIV/HTN care model
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Mucunguzi AtukundaInfectious Diseases Research Collaboration, Kampala, Uganda mucungua@gmail.com.ORCID 0000-0003-4762-0728
Jane KabamiInfectious Diseases Research Collaboration, Kampala, Uganda.
Gerald MutungiNon-Communicable Diseases prevention and control Department, Uganda Ministry of Health, Kampala, Uganda.
Brian TwinamatsikoInfectious Diseases Research Collaboration, Kampala, Uganda.
Joan NangendoMakerere University, Kampala, Uganda.
Starley B ShadeUniversity of California, San Francisco, San Francisco, California, USA.
Edwin CharleboisUniversity of California, San Francisco, San Francisco, California, USA.
Heiner GrosskurthFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
Moses KamyaMakerere University, Kampala, Uganda.
Emmy OkelloUganda Heart Institute, Kampala, Uganda.
Infectious Diseases Research Collaboration · UGMakerere University · UGUniversity of California, San Francisco · USLondon School of Hygiene & Tropical Medicine · GBMinistry of Health · UGUganda Management Institute · UG

Funding

Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Sheri Ann Lippman · 2001 to 2026
$57.4M
NIMH NIH HHS P30 MH062246
6 · The paper itself

Abstract

introductionThere is a high burden of hypertension (HTN) among HIV-infected people in Uganda. However, capacity to prevent, diagnose and treat HTN is suboptimal. This study seeks to leverage the existing HIV-related infrastructure in primary care health facilities (HFs) using the integrated HIV/HTN care model to improve health outcomes of patients with HIV and HTN. METHODS AND ANALYSIS: Integrated HIV/HTN study a type-1 effectiveness/implementation cluster randomised trial, will evaluate the effectiveness of a multicomponent model intervention in 13 districts randomised to the intervention arm compared with 13 districts randomised to control. Two randomly selected HFs per district and their patients will be eligible to participate. The intervention will comprise training of primary healthcare (PHC) providers followed by regular supervision, integration of HTN care into HIV clinics, improvement of the health management information system, IT-based messaging to improve communication among frontline PHCs and district-level managers. HTN care guidelines, sphygmomanometers, patient registers and a buffer stock of essential drugs will be provided to HFs in both study arms. We will perform cross-sectional surveys at baseline, 12 and 24 months, on a random sample of patients attending HFs to measure effectiveness of the integrated care model between 2021 and 2024. We will perform in-depth interviews of providers, patients and healthcare managers to assess barriers and facilitators of integrated care. We will measure the cost of the intervention through microcosting and time-and-motion studies. The outcomes will be analysed taking the clustered structure of the data set into account. ETHICS AND DISSEMINATION: Ethics approval has been obtained from the Research Ethics Committees at London School of Hygiene and Tropical Medicine, and Makerere University School of Medicine. All participants will provide informed consent prior to study inclusion. Strict confidentiality will be applied throughout. Findings will be disseminated to public through meetings, and publications. TRIAL REGISTRATION NUMBER: NCT04624061.

Indexed as

HIV InfectionsHypertensionCross-Sectional StudiesHealth FacilitiesHumansRandomized Controlled Trials as TopicUgandaHIV & AIDSHypertensionPublic health

Identifiers

PMID36600388
PMCPMC9743290
OpenAlexW4310857745

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.