Evidence map›Paper›PMID 36600373›Full record

ArticleBMJ open2022

International variation in evidence-based emergency department management of bronchiolitis: a retrospective cohort study.

Marie-Pier Lirette, Nathan Kuppermann, Yaron Finkelstein, Roger Zemek, Amy C Plint, Todd Adam Florin, Franz E Babl, Stuart Dalziel, Stephen Freedman, Damian Roland and 11 more

Abstract read
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Factors associated with mild bronchiolitis in young infants.Journal of the American College of Emergency Physicians open · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Marie-Pier LiretteDivision of Pediatric Emergency Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Nathan KuppermannThe Departments of Emergency Medicine and Pediatrics, University of California Davis School of Medicine, Sacramento, California, USA.
Yaron FinkelsteinDivision of Pediatric Emergency Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Roger ZemekDivision of Pediatric Emergency Medicine, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.ORCID 0000-0001-7807-2459
Amy C PlintDivision of Pediatric Emergency Medicine, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Todd Adam FlorinDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-4387-2605
Franz E BablEmergency Department, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.ORCID 0000-0002-1107-2187
Stuart DalzielEmergency Department, Starship Children's Health, Auckland, Auckland, New Zealand.
Stephen FreedmanDepartment of Pediatrics, Sections of Pediatric Emergency Medicine and Gastroenterology, Alberta Children's Hospital Research Institute, Calgary, Alberta, Canada.ORCID 0000-0003-2319-6192
Damian RolandPaediatric Emergency Medicine Leicester Academic (PEMLA) Group, Leicester Royal Infirmary, Leicester, UK.
Mark David LyttleEmergency Department, Bristol Royal Hospital for Children, Bristol, UK.ORCID 0000-0002-8634-7210
David SchnadowerDivision of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Dale SteelePediatric Emergency Medicine, Hasbro Children's Hospital, Providence, Rhode Island, USA.ORCID 0000-0002-5689-0255
Ricardo M FernandesDepartment of Pediatrics, Hospital de Santa Maria, Lisboa, Portugal.
Derek StephensHospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada.
Anupam KharbandaDepartment of Pediatric Emergency Medicine, Children's Minnesota, Minneapolis, Minnesota, USA.
David W JohnsonUniversity of Calgary Cumming School of Medicine, Calgary, Alberta, Canada.
Charles MaciasDivision of Pediatric Emergency Medicine, UH Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA.
Javier BenitoPediatric Emergency Department, Cruces University Hospital, Barakaldo, Spain.
Suzanne SchuhHospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada suzanne.schuh@sickkids.ca.ORCID 0000-0001-7567-6919
Pediatric Emergency Research Networks (PERN)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe aimed to evaluate the international variation in the use of evidence-based management (EBM) in bronchiolitis. We hypothesised that management consistent with full-EBM practices is associated with the research network of care, adjusted for patient-level characteristics. Secondary objectives were to determine the association between full-EBM and (1) hospitalisation and (2) emergency department (ED) revisits resulting in hospitalisation within 21 days.

designA secondary analysis of a retrospective cohort study.

setting38 paediatric EDs belonging to the Paediatric Emergency Research Network in Canada, USA, Australia/New Zealand UK/Ireland and Spain/Portugal. PATIENTS: Otherwise healthy infants 2-11 months old diagnosed with bronchiolitis between 1 January 2013 and 31 December, 2013. OUTCOME MEASURES: Primary outcome was management consistent with full-EBM, that is, no bronchodilators/corticosteroids/antibiotics, no chest radiography or laboratory testing. Secondary outcomes included hospitalisations during the index and subsequent ED visits.

results1137/2356 (48.3%) infants received full-EBM (ranging from 13.2% in Spain/Portugal to 72.3% in UK/Ireland). Compared with the UK/Ireland, the adjusted ORs (aOR) of full-EBM receipt were lower in Spain/Portugal (aOR 0.08, 95% CI 0.02 to 0.29), Canada (aOR 0.13 (95% CI 0.06 to 0.31) and USA (aOR 0.16 (95% CI 0.07 to 0.35). EBM was less likely in infants with dehydration (aOR 0.49 (95% CI 0.33 to 0.71)), chest retractions (aOR 0.69 (95% CI 0.52 to 0.91)) and nasal flaring (aOR 0.69 (95% CI 0.52 to 0.92)). EBM was associated with reduced odds of hospitalisation at the index visit (aOR 0.77 (95% CI 0.60 to 0.98)) but not at revisits (aOR 1.17 (95% CI 0.74 to 1.85)).

conclusionsInfants with bronchiolitis frequently do not receive full-EBM ED management, particularly those outside of the UK/Ireland. Furthermore, there is marked variation in full-EBM between paediatric emergency networks, and full-EBM delivery is associated with lower likelihood of hospitalisation. Given the global bronchiolitis burden, international ED-focused deimplementation of non-indicated interventions to enhance EBM is needed.

Indexed as

BronchiolitisHospitalizationBronchodilator AgentsChildDyspneaEmergency Service, HospitalHumansInfantRetrospective StudiesBronchodilator AgentsPaediatric A&E and ambulatory carePaediatric infectious disease & immunisationPAEDIATRICS

Identifiers

PMID36600373
PMCPMC9730363

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.