Evidence map›Paper›PMID 36600372›Full record

ArticleBMJ open2022

Cohort-profile: Household transmission of SARS-CoV-2 in a low-resource community in Rio de Janeiro, Brazil.

Patrícia Brasil, Luana Damasceno, Trevon Fuller, Leonardo S Bastos, Oswaldo G Cruz, Fernando Medeiros, Guilherme Amaral Calvet, Paola Resende, Jimmy Whitworth, Chris Smith and 2 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 6 countries.

Patrícia BrasilInstituto Nacional de Infectologia Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil patricia.brasil@ini.fiocruz.br.ORCID 0000-0001-9555-7976
Luana DamascenoInstituto Nacional de Infectologia Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
Trevon FullerInstituto Nacional de Infectologia Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
Leonardo S BastosScientific Computing Program, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
Oswaldo G CruzScientific Computing Program, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
Fernando MedeirosInstituto Nacional de Infectologia Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
Guilherme Amaral CalvetAcute Febrile Illnesses Clinical Research Laboratory, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.ORCID 0000-0002-3545-5238
Paola ResendeLaboratory of Respiratory Viruses and Measles, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
Jimmy WhitworthInternational Public Health, LSHTM, London, UK.
Chris SmithClinical Research Department, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0001-9238-3202
Marilda M SiqueiraLaboratório de Vírus Respiratórios e do Sarampo, IOC, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
Marilia CarvalhoScientific Computing Program, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
Fundação Oswaldo Cruz · BRInstituto Evandro Chagas · BRFaculdades Oswaldo Cruz · BRInternational Center for Public Health · USInternational Olive Council · ESLondon School of Hygiene & Tropical Medicine · GBUniversity of California, Los Angeles · US

Funding

Medical Research Council MR/V033530/1
6 · The paper itself

Abstract

purposeTo better understand the household transmission of SARS-COV-2 in a low-resource community in Rio de Janeiro during the COVID-19 pandemic (2020-2022).

participantsThis is an open prospective cohort study of children ≤12 years old and their household contacts. During home visits over 24 months, we collected data on sociodemographic characteristics, behavioural data, clinical manifestations of SARS-CoV-2, vaccination status, SARS-CoV-2 (reverse transcription-polymerase chain reaction) RT-PCR and anti-S antibody tests. Among adults, the majority of participants were women (62%). FINDINGS TO DATE: We enrolled 845 families from May 2020 to May 2022. The median number of residents per household was four. The median household density, defined as the number of persons per room, was 0.95. The risk of SARS-CoV-2 occurrence was higher in households with a high number of persons per room. Children were not the principal source of SARS-CoV-2 infections in their households during the first wave of the pandemic. FUTURE PLANS: Future studies will investigate cellular and humoral immune responses to locally circulating SARS-CoV-2 variants, which is relevant for the design of vaccines, antivirals and monoclonal antibodies. We will also engage in outreach to encourage vaccination as a means of limiting the transmission of novel SARS-CoV-2 variants and other emerging pathogens.

Indexed as

COVID-19SARS-CoV-2AdultAntibodiesBrazilChildFemaleHumansMalePandemicsProspective StudiesAntibodiesCommunity child healthCOVID-19Epidemiology

Identifiers

PMID36600372
PMCPMC9729844
OpenAlexW4310808898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.