Evidence map›Paper›PMID 36600054›Full record

ArticleZeitschrift fur Rheumatologie2024

[Immune-mediated inflammatory diseases in Germany : A cross-sectional analysis of comorbidities and pharmacotherapy].

Jan Leipe, Renate Schmelz, Gabriela Riemekasten, Diamant Thaçi, Jörg Henes, Knut Schäkel, Andreas Pinter, Michael Sticherling, Joanna Wegner, Stefano Fusco and 7 more

Open access · hybridAbstract readEnglish Abstract
In one paragraph

Article in Zeitschrift fur Rheumatologie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 1 country.

Jan LeipeSektion Rheumatologie, V. Medizinische Klinik, Universitätsklinikum Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland. jan.leipe@umm.de.ORCID http://orcid.org/0000-0001-9684-9700
Renate SchmelzMedizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus Dresden, Dresden, Deutschland.
Gabriela RiemekastenKlinik für Rheumatologie und klinische Immunologie, Universitätsklinikum Schleswig-Holstein, Lübeck, Deutschland.
Diamant ThaçiInstitut und Exzellenzzentrum für Entzündungsmedizin, Universität zu Lübeck, Schleswig-Holstein, Lübeck, Deutschland.
Jörg HenesZentrum für interdisziplinäre und klinische Immunologie, Rheumatologie und autoinflammatorische Erkrankungen (INDIRA) und innere Medizin II, Universitätsklinikum Tübingen, Tübingen, Deutschland.
Knut SchäkelHautklinik, IZEH - Interdisziplinäres Zentrum für chronisch entzündliche Erkrankungen, Universitätsklinikum Heidelberg, Heidelberg, Deutschland.
Andreas PinterKlinik für Dermatologie, Venerologie und Allergologie, Universtitätsklinikum Frankfurt, Frankfurt, Deutschland.
Michael SticherlingHautklinik, Psoriasiszentrum, Deutsches Zentrum für Immuntherapie, Universitätsklinikum Erlangen, Erlangen, Deutschland.
Joanna WegnerHautklinik und Poliklinik, Universitätsitätsmedizin der Johannes-Gutenberg-Universität Mainz, Mainz, Deutschland.
Stefano FuscoMedizinische Klinik I, Universitätsklinikum Tübingen, Tübingen, Deutschland.
Miriam LinkeKlinik für Dermatologie, Venerologie und Allergologie, Universitätsmedizin Mannheim, Mannheim, Deutschland.
Valeria WeberIGES Institut GmbH, Berlin, Deutschland.
Karina C ManzIGES Institut GmbH, Berlin, Deutschland.
Holger BartzJanssen-Cilag GmbH, Neuss, Deutschland.
Marit RoeckenJanssen-Cilag GmbH, Neuss, Deutschland.
Sandra SchmidtJanssen-Cilag GmbH, Neuss, Deutschland.
Bimba F HoyerKlinik für Innere Medizin I, Sektion Rheumatologie und klinische Immunologie, Universitätsklinikum Schleswig-Holstein, Kiel, Deutschland.
Janssen (Germany) · DEHeidelberg University · DEIGES Institut · DEUniversitätsklinikum Tübingen · DEUniversity Hospital Schleswig-Holstein · DEJohannes Gutenberg University Mainz · DEUniversitätsklinikum Erlangen · DEUniversity Hospital Carl Gustav Carus · DEUniversity of Lübeck · DEUniversity of Mannheim · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmune-mediated inflammatory diseases (IMID) can lead to a substantial disease burden for those affected, in particular by the concomitant occurrence of other IMIDs or in the presence of comorbidities. The care of patients with IMIDs is complex and involves various medical disciplines.

objectiveTo describe the burden of disease and the current routine drug treatment of patients with IMID. MATERIAL AND

methodsThe retrospective cross-sectional analysis was based on statutory health insurance claims data from the InGef database. Prevalent patients with psoriasis (Pso), psoriatic arthritis (PsA), spondylarthritis (SpA), rheumatoid arthritis (RA), Crohn's disease (MC), ulcerative colitis (CU), or connective tissue disease were identified among 3,988,695 insured patients in 2018. The concomitant occurrence of different IMIDs and the extent to which patients with IMID are affected by other comorbidities compared to a reference population were investigated. The current routine drug treatment was described based on the use of predefined forms of treatment.

resultsIn the database 188,440 patients with IMID (4.7%) were identified. Compared to the reference population the prevalence of comorbidities, such as depressive episodes and cardiovascular risk factors was higher in patients with IMID. For MC, CU, RA, and PsA disease-modifying antirheumatic drugs (DMARD) and classical systemic forms of treatment were used most commonly. In Pso, SpA, and connective tissue disease nonsteroidal anti-inflammatory drugs (NSAID) were the most frequently used treatment often in combination with other drugs.

conclusionA considerable number of patients with IMIDs (16.9-27.5%) suffer from different diseases of the IMID group. They are frequently affected by accompanying illnesses and require interdisciplinary medical treatment.

Indexed as

Arthritis, PsoriaticArthritis, RheumatoidPsoriasisSpondylarthritisCross-Sectional StudiesHumansImmunomodulating AgentsRetrospective StudiesImmunomodulating AgentsChronic inflammatory diseasesEpidemiologyPharmacotherapyReal-world evidenceStatutory health insurance data analysis

Identifiers

PMID36600054
PMCPMC10972917
OpenAlexW4313495122

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.