Evidence map›Paper›PMID 36600003›Full record

ReviewNature reviews. Cardiology2023

Epidemiology and modifiable risk factors for atrial fibrillation.

Adrian D Elliott, Melissa E Middeldorp, Isabelle C Van Gelder, Christine M Albert, Prashanthan Sanders

Erratum issuedOpen access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 196 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
196citing papers in PubMed, 10 pooled it
70.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

196 citing papers in PubMed, 10 syntheses or guidelines pooled it, 322 citations in OpenAlex.

  1. Clinical outcomes of continuing vs. discontinuing oral anticoagulation after atrial fibrillation ablation: an updated systematic review and meta-analysis of observational studies and randomized controlled trials.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Pooled it
  2. Alcohol consumption and risk of atrial fibrillation: a pairwise and network meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Pooled it
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  8. Active Compression During External Cardioversion of Atrial Fibrillation: A Meta-Analysis of Randomized Controlled Trials.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2025
    Pooled it
  9. Pooled it
  10. Dietary interventions in the management of atrial fibrillation.Frontiers in cardiovascular medicine · 2024
    Pooled it
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  16. Article
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  19. NovelBiomedicines · 2026
    Article
  20. Understanding the Diseased Atria.Physiology (Bethesda, Md.) · 2026
    Review

136 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Adrian D ElliottCentre for Heart Rhythm Disorders, University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0002-5951-4239
Melissa E MiddeldorpCentre for Heart Rhythm Disorders, University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0002-4106-9771
Isabelle C Van GelderDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Christine M AlbertDepartment of Cardiology, Smidt Heart Institute, Cedars Sinai Medical Center (CMA), Los Angeles, CA, USA.ORCID 0000-0002-2081-1121
Prashanthan SandersCentre for Heart Rhythm Disorders, University of Adelaide, Adelaide, South Australia, Australia. prash.sanders@adelaide.edu.au.ORCID 0000-0003-3803-8429
Cedars-Sinai Medical Center · USRoyal Adelaide Hospital · AUUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global prevalence of atrial fibrillation (AF) has increased substantially over the past three decades and is currently approximately 60 million cases. Incident AF and its clinical consequences are largely the result of risk factors that can be modified by lifestyle changes. In this Review, we provide evidence that the lifetime risk of AF is modified not only by sex and race but also through the clinical risk factor and comorbidity burden of individual patients. We begin by summarizing the epidemiology of AF, focusing on non-modifiable and modifiable risk factors, as well as targets and strategies for the primary prevention of AF. Furthermore, we evaluate the role of modifiable risk factors in the secondary prevention of AF as well as the potential effects of risk factor interventions on the frequency and severity of subsequent AF episodes. We end the Review by proposing strategies that require evaluation as well as global policy changes that are needed for the prevention of incident AF and the management of recurrent episodes in patients already affected by AF.

Indexed as

Atrial FibrillationComorbidityHumansLife StyleRisk Factors

Identifiers

PMID36600003
OpenAlexW4313470793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.