Evidence map›Paper›PMID 36599986›Full record

ArticleNature2023

Metabolic regulation of species-specific developmental rates.

Margarete Diaz-Cuadros, Teemu P Miettinen, Owen S Skinner, Dylan Sheedy, Carlos Manlio Díaz-García, Svetlana Gapon, Alexis Hubaud, Gary Yellen, Scott R Manalis, William M Oldham and 1 more

Erratum issuedAbstract readComparative Study
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed.

  1. Energy constraint on human health.Trends in endocrinology and metabolism: TEM · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. NADThe EMBO journal · 2026
    Article
  10. Article
  11. Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  12. Review
  13. Morphological innovation without gene co-option: thebioRxiv : the preprint server for biology · 2026
    Article
  14. Timing of NAD Deficiency During Organogenesis Dictates Defect Type and Penetrance.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  15. Article
  16. Clocks and Dominoes: Timing Mechanisms of Embryogenesis.bioRxiv : the preprint server for biology · 2026
    Article
  17. Review
  18. Review
  19. Article
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Margarete Diaz-CuadrosDepartment of Genetics, Harvard Medical School, Boston, MA, USA. mdiazcuadros@g.harvard.edu.
Teemu P MiettinenKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-5975-200X
Owen S SkinnerDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Dylan SheedyDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Carlos Manlio Díaz-GarcíaDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4352-2496
Svetlana GaponDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Alexis HubaudDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Gary YellenDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4228-7866
Scott R ManalisKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5223-9433
William M OldhamDepartment of Medicine, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3029-4866
Olivier PourquiéDepartment of Genetics, Harvard Medical School, Boston, MA, USA. pourquie@genetics.med.harvard.edu.ORCID http://orcid.org/0000-0001-5189-1227

Funding

Quantitative and functional characterization of therapeutic resistance in cancerU54CA217377 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MANALIS, SCOTT R · 2017 to 2021
$10.2M
Role of Energy Metabolism in Patterning the Vertebrate Musculo-Skeletal AxisR01HD085121 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI OLIVIER POURQUIE · 2016 to 2026
$6.8M
High-throughput optimization of genetically-encoded fluorescent biosensorsR01GM124038 · NIGMS · HARVARD MEDICAL SCHOOL · PI YELLEN, GARY I · 2017 to 2025
$2.5M
Mechanisms of seizure resistance in a mouse genetic model with altered metabolismR01NS102586 · NINDS · HARVARD MEDICAL SCHOOL · PI YELLEN, GARY I · 2018 to 2022
$1.9M
Characterizing the biochemical regulation of mitochondrial one-carbon metabolismF32GM133047 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI SKINNER, OWEN SAMUEL · 2019 to 2021
$153k
Elucidating the Role of Metabolism in Regulating the Vertebrate Segmentation ClockF31HD100033 · NICHD · HARVARD MEDICAL SCHOOL · PI DIAZ CUADROS, MARGARETE · 2019 to 2020
$64k
NCI NIH HHS U54 CA217377NICHD NIH HHS F31 HD100033NICHD NIH HHS R01 HD085121NIGMS NIH HHS F32 GM133047NIGMS NIH HHS R01 GM124038NINDS NIH HHS R01 NS102586
6 · The paper itself

Abstract

Animals display substantial inter-species variation in the rate of embryonic development despite a broad conservation of the overall sequence of developmental events. Differences in biochemical reaction rates, including the rates of protein production and degradation, are thought to be responsible for species-specific rates of development

Indexed as

Embryo, MammalianEmbryonic DevelopmentAnimalsBiological ClocksCell DifferentiationElectron TransportHumansIn Vitro TechniquesLevilactobacillus brevisMiceMultienzyme ComplexesNADNADH, NADPH OxidoreductasesOxidation-ReductionPluripotent Stem CellsSpecies SpecificityMultienzyme ComplexesNADNADH, NADPH OxidoreductasesNADH oxidase

Identifiers

PMID36599986
PMCPMC9944513

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.