Evidence map›Paper›PMID 36599981›Full record

ArticleNature2023

A quantitative map of nuclear pore assembly reveals two distinct mechanisms.

Shotaro Otsuka, Jeremy O B Tempkin, Wanlu Zhang, Antonio Z Politi, Arina Rybina, M Julius Hossain, Moritz Kueblbeck, Andrea Callegari, Birgit Koch, Natalia Rosalia Morero and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. Article
  3. HIV-1 capsid interactions with Nuclear Pore Complex components support nuclear entry via affinity gradient.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Structure, function and assembly of nuclear pore complexes.Nature reviews. Molecular cell biology · 2026
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Shotaro OtsukaCell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany. shotaro.otsuka@univie.ac.at.ORCID http://orcid.org/0000-0003-3976-0843
Jeremy O B TempkinDepartment of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA, USA.
Wanlu ZhangCell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Antonio Z PolitiCell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-4788-0933
Arina RybinaCell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
M Julius HossainCell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-3303-5755
Moritz KueblbeckCell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Andrea CallegariCell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Birgit KochCell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Natalia Rosalia MoreroCell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Andrej SaliDepartment of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0435-6197
Jan EllenbergCell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany. jan.ellenberg@embl.de.ORCID http://orcid.org/0000-0001-5909-701X
European Molecular Biology Laboratory · DEUniversity of California, San Francisco · USEuropean Bioinformatics Institute · GBMax Perutz Labs · ATMax Planck Institute for Medical Research · DE

Funding

TR&D Project 4. The Imaging Stage: Multiscale Spatiotemporal Modeling of Macromolecular Systems in Cellular NeighborhoodsP41GM109824 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2014 to 2023
$18.8M
Structure-Function Mapping of the Nuclear Pore Complex-RenewalR01GM112108 · NIGMS · ROCKEFELLER UNIVERSITY · PI JOHN D. AITCHISON, MICHAEL P ROUT · 2015 to 2026
$9.1M
IMP: Software for Hybrid Determination of Macromolecular Assembly StructuresR01GM083960 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SALI, ANDREJ · 2008 to 2024
$5.2M
Austrian Science Fund FWF W 1261NIGMS NIH HHS P41 GM109824NIGMS NIH HHS R01 GM083960NIGMS NIH HHS R01 GM112108
6 · The paper itself

Abstract

Understanding how the nuclear pore complex (NPC) is assembled is of fundamental importance to grasp the mechanisms behind its essential function and understand its role during the evolution of eukaryotes

Indexed as

Nuclear PoreNuclear Pore Complex ProteinsHumansInterphaseMitosisSpectrometry, FluorescenceNuclear Pore Complex Proteins

Identifiers

PMID36599981
PMCPMC9849139
OpenAlexW4313546279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.