Evidence map›Paper›PMID 36599956›Full record

ArticleJournal of human genetics2023

Genetic factors associated with serum amylase in a Japanese population: combined analysis of copy-number and single-nucleotide variants.

Zannatun Nayema, Takehiro Sato, Takayuki Kannon, Hiromasa Tsujiguchi, Kazuyoshi Hosomichi, Hiroyuki Nakamura, Atsushi Tajima

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Experimental and therapeutic medicine · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zannatun NayemaDepartment of Bioinformatics and Genomics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Takehiro SatoDepartment of Bioinformatics and Genomics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.ORCID http://orcid.org/0000-0001-9866-0346
Takayuki KannonDepartment of Bioinformatics and Genomics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Hiromasa TsujiguchiDepartment of Hygiene and Public Health, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Kazuyoshi HosomichiDepartment of Bioinformatics and Genomics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Hiroyuki NakamuraDepartment of Hygiene and Public Health, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Atsushi TajimaDepartment of Bioinformatics and Genomics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan. atajima@med.kanazawa-u.ac.jp.ORCID http://orcid.org/0000-0001-6808-5491
Kanazawa University · JP

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 19K22753MEXT | Japan Society for the Promotion of Science (JSPS) 19KK0237
6 · The paper itself

Abstract

Amylase activity and levels in humans are heritable quantitative traits. Although many studies exist on the effects of copy-number variants (CNVs) in amylase genes (AMY) on human phenotypes, such as body mass index (BMI), the genetic factors controlling interindividual variation in amylase levels remain poorly understood. Here, we conducted a genome-wide association study (GWAS) of serum amylase levels (SAL) in 814 Japanese individuals to identify associated single-nucleotide variants (SNVs), after adjusting for non-genetic factors. Diploid copy numbers (CN) of AMY (AMY1, AMY2A, and AMY2B) were measured using droplet digital PCR to examine the association between each diploid CN and SAL. We further assessed the relative contribution of the GWAS-lead SNV and AMY CNVs to SAL. GWAS identified 14 significant SNVs (p < 5 × 10

Indexed as

East Asian PeopleGenome-Wide Association StudyAmylasesDNA Copy Number VariationsHumansNucleotidesAmylasesNucleotides

Identifiers

PMID36599956
PMCPMC10125868
OpenAlexW4313544923

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.