Trial reportScientific reports2023
The effects of low-level laser therapy on muscle strength and functional outcomes in individuals with knee osteoarthritis: a double-blinded randomized controlled trial.
Trial report in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- A systematic review and network meta-analysis on the optimal wavelength of low-level light therapy (LLLT) in treating knee osteoarthritis symptoms.Aging clinical and experimental research · 2024Pooled it
- Additional effect of high-intensity laser therapy with conventional physiotherapy related to pain and function in patients with knee osteoarthritis: a randomized, double-blind, placebo-controlled, 12-week follow-up study.Lasers in medical science · 2025Trial
- Evaluation of vascular photobiomodulation for orofacial pain and tension type headache following COVID 19 in a pragmatic randomized clinical trial.Scientific reports · 2024Trial
- Effectiveness of Korean Red Ginseng on fatigue in patients with rheumatic diseases: a randomized, double-blind, placebo-controlled study.The Korean journal of internal medicine · 2024Trial
- Efficacy of Adjunctive Photobiomodulation in Patellofemoral Pain Syndrome: A Systematic Review and Meta-Analysis.Archives of rehabilitation research and clinical translation · 2026Review
- A novel method for establishing a rat model of knee osteoarthritis: knee joint fixation using medical polyurethane composite wraps.Frontiers in veterinary science · 2026Article
- Photobiomodulation for the treatment of knee osteoarthritis: therapeutic effects and molecular mechanism.Frontiers in cell and developmental biology · 2026Review
- Low-level laser therapy in osteoarthritic pain: A narrative review with an approach to integrated clinical use.Osteoarthritis and cartilage open · 2025Review
- Effects of 650 nm laser acupuncture on cartilage, bone, and skeletal muscle in osteoarthritis.Bone reports · 2025Article
- Effect of laser acupuncture on pain, range of motion, and function in patellofemoral pain syndrome: a randomised controlled trial.Frontiers in medicine · 2025Article
- Review
- A Review of Current Approaches to Pain Management in Knee Osteoarthritis with a Focus on Italian Clinical Landscape.Journal of clinical medicine · 2024Review
- Equine Musculoskeletal Pathologies: Clinical Approaches and Therapeutical Perspectives-A Review.Veterinary sciences · 2024Review
- The Effects of High-Intensity Laser Therapy vs. Low-Level Laser Therapy on Functional Ability and Quadriceps Architecture in Patients with Knee Osteoarthritis: A Single-Blinded Randomized Clinical Trial.Journal of lasers in medical sciences · 2024Article
- Photobiological modulation of hepatoma cell lines and hepatitis B subviral particles secretion in response to 650 nm low level laser treatment.Journal of the Egyptian National Cancer Institute · 2023Article
- Comparison between Low-Level and High-Intensity Laser Therapy as an Adjunctive Treatment for Knee Osteoarthritis: A Randomized, Double-Blind Clinical Trial.Life (Basel, Switzerland) · 2023Article
- Current advances of photobiomodulation therapy in treating knee osteoarthritis.Frontiers in cell and developmental biology · 2023Review
- Efficacy of Low-level Laser Therapy in Minimising Morbidity Associated with Removal of Impacted Mandibular Third Molar - A Comparative Study.Annals of maxillofacial surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to compare the therapeutic effects of low-level laser therapy (LLLT) with 808 and 660 nm wavelength on muscle strength and functional outcomes in individuals with knee osteoarthritis (OA). A total of 47 participants were randomly assigned to the 808 nm, 660 nm, and sham control groups. Two LLLT groups received continuous LLLT with a mean power of 300 mW in different wavelengths at the knee joint 15 min a session three days per week for eight weeks, while the control group received the sham LED treatment. The knee strength and functional performance involving 30-s sit-to-stand, 40 m fast-paced walk, stair climbing, and the TUG test were measured at the baseline and one week after the interventions were completed. The results showed that knee extensor strength was more improved in the 808 nm group as compared to the 660 nm group (p < 0.001, d = 0.57) and the sham control (p < 0.001, d = 0.40), while increased flexor strength was demonstrated in the 808 nm (p = 0.009, d = 0.67) and sham control groups (p < 0.001, d = 0.97). The number of 30-s sit-to-stand was increased only in the 660 nm group (p = 0.006, d = 0.49). All three groups exhibited improvements in the other three functional performance-based tests after the interventions with no statistically significant differences among the groups. In conclusion, both intervention groups improved muscle strength and functional performance as compared to the control group. The 808 nm wavelength group showed better results in knee extensor strength. Therefore, laser therapy is suggested to be integrated into rehabilitation programs to improve muscle strength and functional performance in the population with knee OA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.