Evidence map›Paper›PMID 36599670›Full record

ArticleeNeuro2023

Microglial Expression of the Wnt Signaling Modulator

Nozie D Aghaizu, Sarah Jolly, Satinder K Samra, Bernadett Kalmar, Katleen Craessaerts, Linda Greensmith, Patricia C Salinas, Bart De Strooper, Paul J Whiting

Open access · goldAbstract read
In one paragraph

Article in eNeuro, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Nozie D AghaizuUnited Kingdom Dementia Research Institute at University College London, London WC1E 6BT, United Kingdom nozie.aghaizu@ucl.ac.uk sarah.jolly@ucl.ac.uk.ORCID 0000-0002-6096-1853
Sarah JollyAlzheimer's Research UK Drug Discovery Institute (DDI), University College London, London WC1E 6BT, United Kingdom nozie.aghaizu@ucl.ac.uk sarah.jolly@ucl.ac.uk.
Satinder K SamraUnited Kingdom Dementia Research Institute at University College London, London WC1E 6BT, United Kingdom.
Bernadett KalmarDepartment of Neuromuscular Diseases, University College London Queen Square Motor Neuron Disease Centre, Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom.
Katleen CraessaertsVlaams Instituut voor Biotechnologie Centre for Brain Disease Research, Leuven 3000, Belgium.
Linda GreensmithDepartment of Neuromuscular Diseases, University College London Queen Square Motor Neuron Disease Centre, Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom.
Patricia C SalinasDepartment of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom.
Bart De StrooperUnited Kingdom Dementia Research Institute at University College London, London WC1E 6BT, United Kingdom.
Paul J WhitingUnited Kingdom Dementia Research Institute at University College London, London WC1E 6BT, United Kingdom.
UK Dementia Research Institute · GBAllen Institute for Brain Science · USQueen Mary University of London · GBAlzheimer’s Research UK · GBUniversity College London · GB

Funding

Medical Research Council
6 · The paper itself

Abstract

Wnt signaling is crucial for synapse and cognitive function. Indeed, deficient Wnt signaling is causally related to increased expression of

Indexed as

Alzheimer DiseaseNeurodegenerative DiseasesAnimalsBrainDisease Models, AnimalHumansIntercellular Signaling Peptides and ProteinsMiceMice, TransgenicMicrogliaProteinsRatsWnt Signaling PathwayDKK2 protein, humanDkk2 protein, mouseDkk2 protein, ratIntercellular Signaling Peptides and ProteinsProteinsAlzheimer’s diseasemicroglianeurodegenerationneuroinflammationWnt signaling

Identifiers

PMID36599670
PMCPMC9836029
OpenAlexW4313484835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.