Evidence map›Paper›PMID 36599625›Full record

ArticleArchives of disease in childhood2023

Post-COVID-19 condition at 6 months and COVID-19 vaccination in non-hospitalised children and young people.

Snehal M Pinto Pereira, Manjula D Nugawela, Natalia K Rojas, Roz Shafran, Kelsey McOwat, Ruth Simmons, Tamsin Ford, Isobel Heyman, Shamez N Ladhani, Emily Y Cheung and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of disease in childhood, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
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  6. Review
  7. Long COVID in children and young people: then and now.Current opinion in infectious diseases · 2025
    Review
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  12. Article
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  14. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Snehal M Pinto PereiraUCL Great Ormond Street Institute of Child Health, London, UK snehal.pereira@ucl.ac.uk.ORCID 0000-0002-0876-8757
Manjula D NugawelaUCL Great Ormond Street Institute of Child Health, London, UK.
Natalia K RojasUCL Great Ormond Street Institute of Child Health, London, UK.
Roz ShafranUCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0003-2729-4961
Kelsey McOwatImmunisation Department, Public Health England, London, UK.
Ruth SimmonsImmunisation Department, Public Health England, London, UK.
Tamsin FordDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Isobel HeymanUCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0001-7358-9766
Shamez N LadhaniImmunisation Department, Public Health England, London, UK.ORCID 0000-0002-0856-2476
Emily Y CheungUCL Great Ormond Street Institute of Child Health, London, UK.
Lana Fox-SmithUCL Great Ormond Street Institute of Child Health, London, UK.
Emma DalrympleUCL Great Ormond Street Institute of Child Health, London, UK.
Terence StephensonUCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0001-8871-7847

Funding

Department of HealthMedical Research Council MR/P020372/1
6 · The paper itself

Abstract

objectivesTo describe the physical and mental health of children and young people (CYP) 6 months after infection with SARS-CoV-2 and explore whether this varies by COVID-19 vaccination.

designA non-hospitalised, national cohort of people aged 11-17 years old with PCR-confirmed SARS-CoV-2 infection and PCR negatives matched at study invitation, by age, sex, region and date of testing who completed questionnaires 6 months after PCR testing. The questionnaire included 21 symptoms and standardised scales (eg, EQ-5D-Y and Chalder Fatigue Scale).

results6407 test-positive and 6542 test-negative CYP completed the 6-month questionnaire: 60.9% of test-positive vs 43.2% of test-negative CYP reported at least one symptom 6 months post-test; 27.6% of test-positive vs 15.9% of test-negative CYP reported 3+ symptoms. Common symptoms at 6 months were tiredness and shortness of breath among both test-positive and test-negative CYP; however, the prevalence of both was higher in test-positive (38.4% and 22.8%, respectively) compared with test-negative CYP (26.7% and 10.9%, respectively). 24.5% test-positive vs 17.8% test-negative CYP met the Delphi research definition of long COVID. Mental health, well-being, fatigue and health-related quality of life scores were similar among test-positive and test-negative CYP 6 months post-test. Similarly, symptomatology was similar among COVID-19-vaccinated and COVID-19-unvaccinated test-positive and test-negative CYP.

conclusionsSix-months post-PCR testing, CYP who tested positive for SARS-CoV-2 had similar symptoms to those who tested negative, but test-positive CYP had higher symptom prevalence. Mental health, well-being, fatigue and health-related quality of life were similar among test-positive and test-negative CYP, and symptoms at 6 months were similar in COVID-19 vaccinated and unvaccinated. TRIAL REGISTRATION NUMBER: ISRCTN 34804192.

Indexed as

COVID-19AdolescentChildCOVID-19 VaccinesFatigueHumansInfantPost-Acute COVID-19 SyndromeQuality of LifeSARS-CoV-2VaccinationCOVID-19 Vaccinesadolescent healthchild healthCOVID-19paediatrics

Identifiers

PMID36599625
PMCPMC10086284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.