Evidence map›Paper›PMID 36599624›Full record

ArticleLife science alliance2023

An essential Noc3p dimerization cycle mediates ORC double-hexamer formation in replication licensing.

Aftab Amin, Rentian Wu, Muhammad Ajmal Khan, Man Hei Cheung, Yanting Liang, Changdong Liu, Guang Zhu, Zhi-Ling Yu, Chun Liang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Aftab AminDivision of Life Science, Center for Cancer Research, and State Key Lab of Molecular Neuroscience, Hong Kong University of Science and Technology, Hong Kong, China.ORCID https://orcid.org/0000-0003-3285-3422
Rentian WuDivision of Life Science, Center for Cancer Research, and State Key Lab of Molecular Neuroscience, Hong Kong University of Science and Technology, Hong Kong, China.ORCID https://orcid.org/0000-0003-3862-6394
Muhammad Ajmal KhanDivision of Life Science, Center for Cancer Research, and State Key Lab of Molecular Neuroscience, Hong Kong University of Science and Technology, Hong Kong, China.ORCID https://orcid.org/0000-0002-3817-3631
Man Hei CheungDivision of Life Science, Center for Cancer Research, and State Key Lab of Molecular Neuroscience, Hong Kong University of Science and Technology, Hong Kong, China.ORCID https://orcid.org/0000-0002-4383-7666
Yanting LiangDivision of Life Science, Center for Cancer Research, and State Key Lab of Molecular Neuroscience, Hong Kong University of Science and Technology, Hong Kong, China.ORCID https://orcid.org/0000-0002-3757-3182
Changdong LiuDivision of Life Science, Center for Cancer Research, and State Key Lab of Molecular Neuroscience, Hong Kong University of Science and Technology, Hong Kong, China.ORCID https://orcid.org/0000-0001-7356-9765
Guang ZhuDivision of Life Science, Center for Cancer Research, and State Key Lab of Molecular Neuroscience, Hong Kong University of Science and Technology, Hong Kong, China.ORCID https://orcid.org/0000-0001-9970-4988
Zhi-Ling YuSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China bccliang@ust.hk zlyu@hkbu.edu.hk.ORCID https://orcid.org/0000-0002-2979-9608
Chun LiangDivision of Life Science, Center for Cancer Research, and State Key Lab of Molecular Neuroscience, Hong Kong University of Science and Technology, Hong Kong, China bccliang@ust.hk zlyu@hkbu.edu.hk bccliang@ust.hk zlyu@hkbu.edu.hk.ORCID https://orcid.org/0000-0003-2180-0931
Hong Kong University of Science and Technology · HKHong Kong Baptist University · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Replication licensing, a prerequisite of DNA replication, helps to ensure once-per-cell-cycle genome duplication. Some DNA replication-initiation proteins are sequentially loaded onto replication origins to form pre-replicative complexes (pre-RCs). ORC and Noc3p bind replication origins throughout the cell cycle, providing a platform for pre-RC assembly. We previously reported that cell cycle-dependent ORC dimerization is essential for the chromatin loading of the symmetric MCM double-hexamers. Here, we used

Indexed as

Protein MultimerizationSaccharomyces cerevisiae ProteinsCell CycleDimerizationDNA ReplicationNuclear ProteinsNucleocytoplasmic Transport ProteinsOrigin Recognition ComplexSaccharomyces cerevisiaeNOC3 protein, S cerevisiaeNuclear ProteinsNucleocytoplasmic Transport ProteinsOrigin Recognition ComplexSaccharomyces cerevisiae Proteins

Identifiers

PMID36599624
PMCPMC9813392
OpenAlexW4313482857

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.