Evidence map›Paper›PMID 36599466›Full record

ArticleThorax2023

Lymphangioleiomyomatosis (LAM) Cell Atlas.

Yina Du, Minzhe Guo, Yixin Wu, Andrew Wagner, Anne Karina Perl, Kathryn Wikenheiser-Brokamp, Jane Yu, Nishant Gupta, Elizabeth Kopras, Vera Krymskaya and 6 more

Open access · greenAbstract read
In one paragraph

Article in Thorax, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. The Bi-steric Inhibitor RMC-5552 Reduces mTORC1 Signaling and Growth in Lymphangioleiomyomatosis.American journal of respiratory cell and molecular biology · 2025
    Article
  7. Article
  8. Article
  9. Lost in translation: a neglected mTOR target for lymphangioleiomyomatosis.European respiratory review : an official journal of the European Respiratory Society · 2023
    Review
  10. Review
  11. Article
  12. [Highlights 57th SEPAR Congress].Open respiratory archives
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Yina DuThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Minzhe GuoThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Yixin WuThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Andrew WagnerThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Anne Karina PerlThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Kathryn Wikenheiser-BrokampThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Jane YuDivision of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Nishant GuptaUniversity of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0001-9112-1315
Elizabeth KoprasDivision of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Vera KrymskayaMedicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Kseniya ObraztsovaDivision of Pulmonary, Allergy, and Critical Care Medicine, Lung Biology Institute, Perelman School of Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Yan TangDivision of Pulmonary and Critical Care Medicine, Harvard Medical School, Boston, Massachusetts, USA.
David KwiatkowskiDivision of Pulmonary and Critical Care Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Elizabeth P HenskeDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Francis McCormackDivision of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Yan XuThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA Yan.Xu@cchmc.org.ORCID 0000-0003-2025-027X
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati Medical Center · USHarvard University · USUniversity of Pennsylvania · USBrigham and Women's Hospital · US

Funding

The Molecular and Genetic Pathogensis of LAMU01HL131022 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HENSKE, ELIZABETH P · 2016 to 2024
$5.7M
LungMap Phase II - Building a multidimensional map of developing human lungU01HL148856 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI WHITSETT, JEFFREY A, XU, YAN · 2019 to 2023
$4.5M
RLDC: Molecular Pathway-Driven Diagnostics & Therapeutics for Rare Lung DiseasesU54HL127672 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TRAPNELL, BRUCE C · 2014 to 2018
$3.7M
Multicenter Interventional Lymphangioleiomyomatosis Early Disease Trial (MILED)-CCCU01HL131755 · NHLBI · UNIVERSITY OF CINCINNATI · PI MCCORMACK, FRANCIS XAVIER · 2016 to 2021
$3.6M
Mechanisms linking hot flashes to cardiovascular riskR01HL105647 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THURSTON, REBECCA C · 2011 to 2015
$3.2M
Uterine signaling networks in the pathogenesis of pulmonary lymphangioleiomyomatosis (LAM)R01HL153045 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI XU, YAN, YU, JANE · 2020 to 2023
$3.1M
mTORC1 and WNT in lung mesenchymeR01HL158737 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KRYMSKAYA, VERA P · 2021 to 2024
$2.5M
mTOR signaling in lung homeostasis, aging and diseaseR01HL151467 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KRYMSKAYA, VERA P · 2020 to 2023
$2.0M
Interstitial resident fibroblasts direct alveolar epithelial differentiationR01HL131661 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI PERL, ANNE-KARINA THERESIA · 2017 to 2020
$1.9M
Urokinase-type plasminogen activator (uPA) in pathogenesis of lymphangioleiomyomatosis (LAM)R01HL141462 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KRYMSKAYA, VERA P, STEPANOVA, VICTORIA · 2019 to 2022
$1.8M
Genetics of LAMR01HL156010 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KWIATKOWSKI, DAVID J. · 2021 to 2024
$1.8M
FGF and PDGF regulate myofibroblast differentiation in alveolar regenerationR01HL104003 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI PERL, ANNE-KARINA THERESIA · 2010 to 2013
$1.5M
NHLBI NIH HHS R01 HL104003NHLBI NIH HHS R01 HL105647NHLBI NIH HHS R01 HL131661NHLBI NIH HHS R01 HL141462NHLBI NIH HHS R01 HL151467NHLBI NIH HHS R01 HL153045NHLBI NIH HHS R01 HL156010NHLBI NIH HHS R01 HL158737NHLBI NIH HHS U01 HL131022NHLBI NIH HHS U01 HL131755NHLBI NIH HHS U01 HL148856NHLBI NIH HHS U54 HL127672
6 · The paper itself

Abstract

Lymphangioleiomyomatosis (LAM) is a rare lung disease of women, causing cystic remodelling of the lung and progressive respiratory failure. The cellular composition, microenvironment and cellular interactions within the LAM lesion remain unclear. To facilitate data sharing and collaborative LAM research, we performed an integrative analysis of single-cell data compiled from lung, uterus and kidney of patients with LAM from three research centres and developed an LAM Cell Atlas (LCA) Web-Portal. The LCA offers a variety of interactive options for investigators to search, visualise and reanalyse comprehensive single-cell multiomics data sets to reveal dysregulated genetic programmes at transcriptomic, epigenomic and cell-cell connectome levels.

Indexed as

Lung DiseasesLung NeoplasmsLymphangioleiomyomatosisRespiratory InsufficiencyFemaleHumansLungTranscriptomeTumor Microenvironmentcystic fibrosisidiopathic pulmonary fibrosislung cancerpulmonary lymphomarare lung diseases

Identifiers

PMID36599466
PMCPMC10280816
OpenAlexW4294884495

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.