ArticleNature2023
Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19.
Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04025580 (Systems Analyses of the Immune Response to the Seasonal Influenza Vaccine), which is not on this map. Cited by 55 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
14.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Systems Analyses of the Immune Response to the Seasonal Influenza Vaccine
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Mucosal immune response in biology, disease prevention and treatment.Signal transduction and targeted therapy · 2025Pooled it
- NS1-Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A pre-trained large generative model for translating single-cell transcriptomes to proteomes.Nature biomedical engineering · 2026Article
- Review
- Human vaccine responses regulated by parallel cytokine pathways.Nature immunology · 2026Article
- Acquired immunodeficiency syndrome-associated cytomegalovirus encephalitis: clinical, imaging, and follow-up characteristics of 11 cases.Quantitative imaging in medicine and surgery · 2026Article
- Identification of biomarkers associated with integrated stress response in pituitary adenomas based on bioinformatics.Discover oncology · 2026Article
- Sex differences in immune responses to viruses, bacteria and vaccines.Nature immunology · 2026Review
- Mortality trends in older adults (55-84 years) with sepsis-atrial fibrillation: a CDC database analysis.BMC public health · 2026Article
- Immune Priming and the Risk of COVID-19, Influenza, and Other Acute Respiratory Infections: Insights From an N3C Cohort.Influenza and other respiratory viruses · 2026Article
- shinyDeepGxP: a user-friendly R shiny app for predicting surface protein abundance from scRNA-seq expression using deep learning in blood cells.Bioinformatics advances · 2026Article
- Influenza vaccination post-COVID-19 expands vaccine-specific effector CD4 T-cells and Tregs under positive influence of host trained innate immunity.NPJ vaccines · 2025Article
- Screening for next generation vaccines in human immune organoids.ImmunoHorizons · 2025Review
- Review
- Long-term impact of COVID-19 in patients with lung cancer receiving immune checkpoint inhibitors: a multicenter cohort study during Omicron pandemic.BMC infectious diseases · 2025Article
- Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functions.Nature methods · 2025Article
- Constraints and tunability of antigen-agnostic memory durability.bioRxiv : the preprint server for biology · 2025Article
- Contrasting interferon-mediated antiviral responses in human lung adenocarcinoma cells.Journal of virology · 2025Article
- Healthy Aging Metabolomic and Proteomic Signatures Across Multiple Physiological Compartments.Aging cell · 2025Article
- BNT162b2 COVID-19 vaccination elicits the expansion of CD16The Journal of allergy and clinical immunology · 2025Article
Corrections and comments
- Update of
Authors and funding
28 authors at 8 institutions in 1 country.
Rachel Sparks *Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-8216-5084
William W Lau *Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA.
Can Liu *Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-8411-3891
Kyu Lee HanNIH Center for Human Immunology, NIAID, NIH, Bethesda, MD, USA.
Kiera L VrindtenMultiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0612-0420
Guangping SunMultiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA.
Milann CoxMultiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA.
Sarah F AndrewsVaccine Research Center, NIAID, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-2583-1949
Neha BansalMultiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA.
Laura E FaillaMultiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA.
Jody ManischewitzDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, USA.
Gabrielle GrubbsDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, USA.
Lisa R KingDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, USA.
Galina KorolevaNIH Center for Human Immunology, NIAID, NIH, Bethesda, MD, USA.
Stephanie LeimenstollLaboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA.
LaQuita SnowLaboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA.
OP11 Clinical Staff
Jinguo ChenNIH Center for Human Immunology, NIAID, NIH, Bethesda, MD, USA.
Juanjie TangDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, USA.
Amrita MukherjeeNIH Center for Human Immunology, NIAID, NIH, Bethesda, MD, USA.
Brian A SellersNIH Center for Human Immunology, NIAID, NIH, Bethesda, MD, USA.
Richard AppsNIH Center for Human Immunology, NIAID, NIH, Bethesda, MD, USA.
Adrian B McDermottVaccine Research Center, NIAID, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-0616-9117
Andrew J MartinsMultiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA.
Evan M BlochDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-8181-9517
Hana GoldingDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, USA.
Surender KhuranaDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, USA.ORCID http://orcid.org/0000-0002-0593-7965
John S TsangMultiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA. john.tsang@yale.edu.ORCID http://orcid.org/0000-0003-3186-3047
National Institutes of Health Clinical Center · USCenter for Biologics Evaluation and Research · USNational Institutes of Health · USFrederick National Laboratory for Cancer Research · USJohns Hopkins University · USOffice of Extramural Research · USUnited States Department of Health and Human Services · USUniversity of Maryland, College Park · US
Funding
WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6MVaccine Immunology ProgramZIAAI005143 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KOUP, RICHARD A · 2019 to 2025
$51.8MCenter for Human Immunology ZICAI001226 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CHERRY, JAMES · 2018 to 2025
$34.1MSystems immunology of influenza vaccination responses in healthy COVID-19 recovered individual versus those with no history of COVID-19ZIAAI001359 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SPARKS, RACHEL · 2022 to 2023
$762kIntramural NIH HHS ZIA AI001359NCI NIH HHS 75N91019D00024
Abstract
Acute viral infections can have durable functional impacts on the immune system long after recovery, but how they affect homeostatic immune states and responses to future perturbations remain poorly understood
Indexed as
COVID-19Immunity, InnateImmunologic MemoryInfluenza VaccinesSex CharacteristicsT-LymphocytesVaccinationCD8-Positive T-LymphocytesFemaleHealthy VolunteersHumansInfluenza, HumanInterferon-gammaInterleukin-15MaleMonocytesIFNG protein, humanInfluenza VaccinesInterferon-gammaInterleukin-15Toll-Like Receptors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT04025580ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.