ArticleNature2023
Identification of astrocyte regulators by nucleic acid cytometry.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
12.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- CRISPR and Myelin regeneration: a systematic review of applications in demyelinating CNS Disorders, with a focus on MS.Regenerative medicine · 2025Pooled it
- Tools and tactics for studying alternative splicing.Nature reviews. Genetics · 2026Review
- Glial cells in chronic inflammation: diversity, dysfunction and therapeutic targeting.Nature reviews. Immunology · 2026Review
- Astrocyte Functional Heterogeneity in Multiple Sclerosis.Journal of clinical neurology (Seoul, Korea) · 2026Review
- Transcript-guided targeted cell enrichment for scalable single-nucleus RNA sequencing.Cell genomics · 2026Article
- AI-integrated microfluidics for drug screening: From single cell to organ-on-a-chip.Acta pharmaceutica Sinica. B · 2026Review
- Droplet Digital CRISPR for Nucleic Acid Detection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- [XVII Post-ECTRIMS Meeting: Review of the New Developments Presented at the 2024 ECTRIMS Congress (I)].Revista de neurologia · 2026Review
- From cellular heterogeneity to precision medicine: single-cell multi-omics in CNS disease research.Frontiers in cellular neuroscience · 2026Review
- Astrocytes as Therapeutic Targets in Neurodegenerative Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Research progress of single cell RNA sequencing in nervous system.Molecular biology reports · 2025Review
- Modeling neurodegeneration in the retina and strategies for developing pan-neurodegenerative therapies.Molecular neurodegeneration · 2025Review
- NR3C1-mediated epigenetic regulation suppresses astrocytic immune responses in mice.Nature communications · 2025Article
- Single cell technologies and the biology of HIV-infected CD4 T-cell reservoirs.Current opinion in HIV and AIDS · 2025Review
- Activity and Heterogeneity of Astrocytes in Neurological Diseases: Molecular Mechanisms and Therapeutic Targets.MedComm · 2025Review
- Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies.Nature communications · 2025Article
- Article
- A focus on the normal-appearing white and gray matter within the multiple sclerosis brain: a link to smoldering progression.Acta neuropathologica · 2025Review
- Deterministic Cell Pairing with Simultaneous Microfluidic Merging and Sorting of Droplets.bioRxiv : the preprint server for biology · 2025Article
- Mutations in the human CSF1R gene impact microglia's maintenance of brain white matter integrity.Nature immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 6 institutions in 2 countries.
Iain C Clark *Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9082-0253
Michael A Wheeler *Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0689-6384
Hong-Gyun LeeAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5960-5504
Zhaorong LiAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5268-6986
Liliana M SanmarcoAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Shravan ThaplooAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Carolina M PolonioAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0460-0161
Seung Won ShinDepartment of Bioengineering, College of Engineering, California Institute for Quantitative Biosciences, QB3, University of California Berkeley, Berkeley, CA, USA.
Giulia ScalisiAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Amy R HenryVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Joseph M RoneAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Federico GiovannoniAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Marc CharabatiAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Camilo Faust AklAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Dulce M AlemanAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Stephanie E J ZandeeNeuroimmunology Research Lab, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.
Alexandre PratNeuroimmunology Research Lab, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0001-6188-0580
Daniel C DouekVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Eli A BoritzVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Francisco J QuintanaAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. fquintana@rics.bwh.harvard.edu.ORCID http://orcid.org/0000-0001-8156-0736
Adam R AbateDepartment of Bioengineering and Therapeutic Sciences, School of Pharmacy, University of California San Francisco, San Francisco, CA, USA. adam@abatelab.org.ORCID http://orcid.org/0000-0001-9614-4831
Brigham and Women's Hospital · USBroad Institute · USNational Institutes of Health · USCentre Hospitalier de l’Université de Montréal · CAQB3 · USUniversity of California, San Francisco · US
Funding
Delaney AIDS Research Enterprise to Cure HIVUM1AI126611 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEEKS, STEVEN GRANT, PICKER, LOUIS J. · 2016 to 2020
$27.9MThe Genome Analysis CoreZICAI005133 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DOUEK, DANIEL CESAR · 2019 to 2025
$16.9MHIV persistence in vivoZIAAI005131 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BORITZ, ELI · 2017 to 2025
$14.5MThe HIV ReservoirZIAAI005034 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DOUEK, DANIEL CESAR · 2009 to 2025
$7.5MMulti-omic dissection of the transcriptional, epigenetic, and proteomic signatures of cells infected with latent HIVR01AI149699 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI ABATE, ADAM R., QUINTANA, FRANCISCO J. · 2020 to 2024
$3.8MRole of AHR in Dendritic Cells in the Control of the CNS AutoimmunityR01ES025530 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI Francisco J. Quintana · 2016 to 2026
$3.7MGene-by-environment interactions that affect exposure-mediated congenital heart diseaseR01ES032323 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAHN, MARK E, WHITEHEAD, JOHN ANDREW · 2021 to 2025
$3.1MDecoding the language of inflammation between central nervous system resident immune cellsDP2AI154435 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Iain Clark · 2021 to 2026
$2.4MControl of extracellular matrix remodeling by CD29+ astrocytesR01MH130458 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI Michael Alex Wheeler · 2022 to 2026
$2.1MRegulation of CNS AutoimmunityR01AI126880 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI QUINTANA, FRANCISCO J. · 2017 to 2021
$2.1MPathogenic Astrocyte Populations in EAE and MSR01NS129778 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI Francisco J. Quintana · 2023 to 2026
$1.7MSINGLE-CELL TRANSCRIPTOMIC ANALYSIS OF HIV-INFECTED CD4 T CELLS IN BLOOD AND LYMPHOID TISSUE USING PCR-ACTIVATED CELL SORTINGU01AI129206 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABATE, ADAM R., BORITZ, ELI A · 2017 to 2020
$1.6MNIAID NIH HHS DP2 AI154435NIAID NIH HHS K22 AI152644NIAID NIH HHS R01 AI126880NIAID NIH HHS R01 AI149699NIAID NIH HHS U01 AI129206NIAID NIH HHS UM1 AI126611NIEHS NIH HHS R01 ES025530NIEHS NIH HHS R01 ES032323NIMH NIH HHS R01 MH130458NINDS NIH HHS F32 NS101790NINDS NIH HHS K99 NS114111NINDS NIH HHS R00 NS114111NINDS NIH HHS R01 NS129778NINDS NIH HHS R21 NS087867Wellcome Trust
Abstract
Multiple sclerosis is a chronic inflammatory disease of the central nervous system
Indexed as
AstrocytesEncephalomyelitis, Autoimmune, ExperimentalMicrofluidicsMultiple SclerosisNucleic AcidsSingle-Cell Gene Expression AnalysisAnimalsGene EditingGene Expression RegulationHumansMiceMice, KnockoutNuclear Receptor Co-Repressor 2Receptors, MineralocorticoidX-Box Binding Protein 1NCOR2 protein, humanNcor2 protein, mouseNR3C2 protein, humanNr3c2 protein, mouseNuclear Receptor Co-Repressor 2Nucleic AcidsReceptors, MineralocorticoidX-Box Binding Protein 1XBP1 protein, humanXbp1 protein, mouse
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.