Evidence map›Paper›PMID 36599302›Full record

ArticleCell metabolism2023

Illuminating lactate in cells, mice, and patient samples.

Zefan Li, Hui-Wang Ai

Abstract readComment
In one paragraph

Article in Cell metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Chemical Bond-Orchestrated Energy Depletion to Augment Lung Cancer Chemo-Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Zefan LiDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Center for Membrane and Cell Physiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Hui-Wang AiDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Center for Membrane and Cell Physiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; The UVA Comprehensive Cancer Center, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: huiwang.ai@virginia.edu.

Funding

Next-Gen Fluorescent Indicators for Imaging Synaptic Zinc in Cortical Sound ProcessingR01EB033172 · NIBIB · UNIVERSITY OF VIRGINIA · PI Huiwang Ai, Thanos Tzounopoulos · 2022 to 2026
$3.3M
Red and Far-Red Fluorescent Biosensors for Compartmentalized Redox SignalingR01GM129291 · NIGMS · UNIVERSITY OF VIRGINIA · PI AI, HUIWANG · 2018 to 2021
$2.1M
An Integrated Fluorescent Biosensor, Imaging, and Analysis Toolkit for Islet BiologicsR01DK122253 · NIDDK · UNIVERSITY OF VIRGINIA · PI AI, HUIWANG · 2020 to 2023
$1.6M
Fluorescent Redox Indicators to Image Oxidative Stress in Alzheimer's DiseaseRF1AG077773 · NIA · UNIVERSITY OF VIRGINIA · PI AI, HUIWANG · 2022 to 2022
$1.6M
NIA NIH HHS RF1 AG077773NIBIB NIH HHS R01 EB033172NIDDK NIH HHS R01 DK122253NIGMS NIH HHS R01 GM129291
6 · The paper itself

Abstract

Lactate has emerged as a central metabolic fuel and an important signaling molecule. In this issue of Cell Metabolism, Li et al. develop a high-quality lactate sensor, allowing them to monitor lactate levels in cells, subcellular organelles, live mice, and human body fluids.

Indexed as

Lactic AcidSignal TransductionAnimalsHumansMiceLactic Acid

Identifiers

PMID36599302
PMCPMC9883804

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.