ArticleScience advances2023
Auxin promotes hypocotyl elongation by enhancing BZR1 nuclear accumulation in
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 64 citations in OpenAlex.
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- Origin and evolution ofHorticulture research · 2026Article
- MPK3 as a Signalling Hub in Plants: Integrating Plant Growth, Development and Stress Response.Plants (Basel, Switzerland) · 2026Article
- CUL3Science advances · 2026Article
- BrPIF4/BrBBX24-BrHB52-mediated hypocotyl modularity unlocks mechanized harvesting potential inHorticulture research · 2026Article
- Genome-wide identification and analysis of the cysteine-rich transmembrane module genes in Chinese cabbage (Brassica rapa L. ssp. Pekinensis) and BrCYSTM1 is involved in leaf size development.BMC plant biology · 2026Article
- Identification of genetic loci and domestication gene GmZFP1 associated with soybean hypocotyl elongation in seedling stage by genome-wide association study.BMC plant biology · 2026Article
- Boron Toxicity Modulates Hypocotyl Growth Through Brassinosteroid and Thermomorphogenic-Like Mechanisms.Plant, cell & environment · 2025Article
- Brassinosteroid Synthesis and Perception Differently Regulate Phytohormone Networks inInternational journal of molecular sciences · 2025Article
- SRAS1.1 E3 ligase mediates DSK2A degradation to regulate autophagy and drought tolerance in Arabidopsis.EMBO reports · 2025Article
- pMAGs: A Versatile and Efficient Vector System for Multi-Gene Studies in Plants.Plants (Basel, Switzerland) · 2025Article
- OsCDPK24 and OsCDPK28 phosphorylate heat shock factor OsHSFA4d to orchestrate abiotic and biotic stress responses in rice.Nature communications · 2025Article
- BZR1 promotes pluripotency acquisition and callus development through direct regulation of ARF7 and ARF19.EMBO reports · 2025Article
- Hormonal and Transcriptomic Insights into Inflorescence Stalk Elongation in Oil Palm.Plants (Basel, Switzerland) · 2025Article
- PtrSAUR32 Interacts with PtrPP2C.Ds to Regulate Root Growth in Citrus.Plants (Basel, Switzerland) · 2025Article
- Understanding the Brassinosteroid-Dependent Environmental Adaption in Brassicaceae Plants.Plants (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Auxin and brassinosteroids (BRs) are two major growth-promoting phytohormones that shape hypocotyl elongation; however, the cross-talk between auxin and BR in this process is not fully understood. In this study, we found that auxin-induced hypocotyl elongation is dependent on brassinazole-resistant 1 (BZR1), a core BR signaling component. Auxin promotes BZR1 nuclear accumulation in hypocotyl cells, a process dependent on mitogen-activated protein kinase 3 (MPK3) and MPK6, which are both activated by auxin and whose encoding genes are highly expressed in hypocotyls. We determined that MPK3/MPK6 phosphorylate and reduce the protein stability of general regulatory factor 4 (GRF4), a member of the 14-3-3 family of proteins that retain BZR1 in the cytoplasm. In summary, this study reveals the molecular mechanism by which auxin promotes hypocotyl elongation by enhancing BZR1 nuclear accumulation via MPK3/MPK6-regulated GRF4 protein stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.