Evidence map›Paper›PMID 36598980›Full record

ArticleScience advances2023

An antisteatosis response regulated by oleic acid through lipid droplet-mediated ERAD enhancement.

Jorge Iván Castillo-Quan, Michael J Steinbaugh, Laura Paulette Fernández-Cárdenas, Nancy K Pohl, Ziyun Wu, Feimei Zhu, Natalie Moroz, Veronica Teixeira, Monet S Bland, Nicolas J Lehrbach and 3 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
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  7. Fatty acid regulation of feeding inProceedings of the National Academy of Sciences of the United States of America · 2026
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  16. Iron-deplete diet enhancesbioRxiv : the preprint server for biology · 2025
    Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Jorge Iván Castillo-QuanSection on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Boston, MA, USA.ORCID 0000-0002-6324-2854
Michael J SteinbaughSection on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Boston, MA, USA.ORCID 0000-0002-2403-2221
Laura Paulette Fernández-CárdenasSection on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Boston, MA, USA.ORCID 0000-0002-4976-6467
Nancy K PohlSection on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Boston, MA, USA.ORCID 0000-0002-9173-3247
Ziyun WuSection on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Boston, MA, USA.ORCID 0000-0001-8239-1890
Feimei ZhuSection on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Boston, MA, USA.
Natalie MorozSection on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Boston, MA, USA.ORCID 0000-0003-3200-9168
Veronica TeixeiraSection on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Boston, MA, USA.ORCID 0000-0002-6464-0520
Monet S BlandSection on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Boston, MA, USA.
Nicolas J LehrbachDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7342-4136
Lorenza MoronettiSection on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Boston, MA, USA.ORCID 0000-0002-8541-4688
Magdalena TeuflSection on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Boston, MA, USA.ORCID 0000-0003-3794-0568
T Keith BlackwellSection on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Boston, MA, USA.ORCID 0000-0003-3763-9134
Joslin Diabetes Center · USHarvard University · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
Signaling mechanisms that detect stress and maintain homeostasis - Research Supplement to Promote Diversity in Health-Related ResearchR35GM122610 · NIGMS · JOSLIN DIABETES CENTER · PI KAHN, C RONALD · 2017 to 2025
$4.7M
Uncovering Conserved Lipid Homeostasis Mechanisms that Mediate Longevity after Germ Cell Loss in C. ElegansR01AG054215 · NIA · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 2017 to 2026
$3.9M
NIA NIH HHS R01 AG054215NIDDK NIH HHS P30 DK036836NIGMS NIH HHS R35 GM122610
6 · The paper itself

Abstract

Although excessive lipid accumulation is a hallmark of obesity-related pathologies, some lipids are beneficial. Oleic acid (OA), the most abundant monounsaturated fatty acid (FA), promotes health and longevity. Here, we show that OA benefits

Identifiers

PMID36598980
PMCPMC9812393
OpenAlexW4313545131

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.