ArticleScience advances2023
Reconstruction of distinct vertebrate gastrulation modes via modulation of key cell behaviors in the chick embryo.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- RESEARCH NOTE: Effect of inhibition of bone morphogenetic protein signaling pathway by dorsomorphin on the establishment of embryo polarity.Poultry science · 2026Article
- Non-Canonical MaternalBiology · 2026Article
- StrainMapperJ: An Easy-to-Use Digital Image Correlation Toolkit for Exploring and Quantifying the Mechanics of Deforming Tissues.Results and problems in cell differentiation · 2026Article
- Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction.Nature communications · 2025Article
- Developmental system drift and modular gene regulatory networks shape gastrulation inLife science alliance · 2025Article
- A model for boundary-driven tissue morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Coping with uncertainty: Challenges for robust pattern formation in dynamical tissues.Seminars in cell & developmental biology · 2025Review
- Dynamical systems of fate and form in development.Seminars in cell & developmental biology · 2025Review
- Advances in mechanochemical modelling of vertebrate gastrulation.Biochemical Society transactions · 2025Article
- A multi-tiered mechanical mechanism shapes the early neural plate.Nature communications · 2025Article
- Control of tissue flows and embryo geometry in avian gastrulation.Nature communications · 2025Article
- Article
- Bilateral cellular flows display asymmetry prior to left-right organizer formation in amniote gastrulation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Bilateral cellular flows display asymmetry prior to left-right organizer formation in amniote gastrulation.bioRxiv : the preprint server for biology · 2024Article
- Morphogens in the evolution of size, shape and patterning.Development (Cambridge, England) · 2024Review
- Article
- Coupling and uncoupling of midline morphogenesis and cell flow in amniote gastrulation.bioRxiv : the preprint server for biology · 2024Article
- A mechanochemical model recapitulates distinct vertebrate gastrulation modes.Science advances · 2023Article
- From shape-shifting embryonic cells to oncology: The fascinating history of epithelial mesenchymal transition.Seminars in cancer biology · 2023Review
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The morphology of gastrulation driving the internalization of the mesoderm and endoderm differs markedly among vertebrate species. It ranges from involution of epithelial sheets of cells through a circular blastopore in amphibians to ingression of mesenchymal cells through a primitive streak in amniotes. By targeting signaling pathways controlling critical cell behaviors in the chick embryo, we generated crescent- and ring-shaped mesendoderm territories in which cells can or cannot ingress. These alterations subvert the formation of the chick primitive streak into the gastrulation modes seen in amphibians, reptiles, and teleost fish. Our experimental manipulations are supported by a theoretical framework linking cellular behaviors to self-organized multicellular flows outlined in detail in the accompanying paper. Together, this suggests that the evolution of gastrulation movements is largely determined by changes in a few critical cell behaviors in the mesendoderm territory across different species and controlled by a relatively small number of signaling pathways.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.