Evidence map›Paper›PMID 36598946›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Re-formation of synaptic connectivity in dissociated human stem cell-derived retinal organoid cultures.

Allison L Ludwig, Steven J Mayerl, Yu Gao, Mark Banghart, Cole Bacig, Maria A Fernandez Zepeda, Xinyu Zhao, David M Gamm

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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  5. A highly reproducible and efficient method for retinal organoid differentiation from human pluripotent stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Allison L LudwigComparative Biomedical Sciences Graduate Program, University of Wisconsin-Madison, Madison, WI 53705.ORCID 0000-0002-3327-9795
Steven J MayerlWaisman Center, University of Wisconsin-Madison, Madison, WI 53705.
Yu GaoWaisman Center, University of Wisconsin-Madison, Madison, WI 53705.
Mark BanghartDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53705.
Cole BacigWaisman Center, University of Wisconsin-Madison, Madison, WI 53705.
Maria A Fernandez ZepedaWaisman Center, University of Wisconsin-Madison, Madison, WI 53705.
Xinyu ZhaoWaisman Center, University of Wisconsin-Madison, Madison, WI 53705.ORCID 0000-0002-5128-4424
David M GammComparative Biomedical Sciences Graduate Program, University of Wisconsin-Madison, Madison, WI 53705.
University of Wisconsin–Madison · US

Funding

WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MAILICK, MARSHA RUTH · 1985 to 2015
$25.2M
Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Brittany Gail Travers · 2021 to 2026
$8.5M
Retinal disease models for translational photoreceptor replacementU24EY029890 · NEI · CHILDREN'S HOSP OF PHILADELPHIA · PI BELTRAN, WILLIAM A., GAMM, DAVID M · 2018 to 2022
$7.3M
Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MESSING, ALBEE · 2016 to 2020
$6.0M
Screening for Molecules that Promote Photoreceptor SynaptogenesisU01EY027266 · NEI · JOHNS HOPKINS UNIVERSITY · PI GAMM, DAVID M, ZACK, DONALD J. · 2016 to 2018
$2.3M
The Role of MDM2 in FMRP regulation of neuronal developmentR01MH116582 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI ZHAO, XINYU · 2018 to 2022
$2.2M
The role of RNA binding protein in FXR1P in interneuronsR01MH118827 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI ZHAO, XINYU · 2019 to 2023
$2.2M
Integration of Experience-Induced Gene Expression and Circuit FunctionsR01NS105200 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI JACKSON, MEYER B., ZHAO, XINYU · 2018 to 2022
$2.0M
Toward enhancing organization and defining synaptic connectivity of transplanted human pluripotent stem cell-derived photoreceptor graftsF30EY031230 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI LUDWIG, ALLISON LYN · 2020 to 2023
$163k
NEI NIH HHS F30 EY031230NEI NIH HHS U01 EY027266NEI NIH HHS U24 EY029890NICHD NIH HHS P50 HD105353NICHD NIH HHS U54 HD090256NIMH NIH HHS R01 MH116582NIMH NIH HHS R01 MH118827NINDS NIH HHS R01 NS105200
6 · The paper itself

Abstract

Human pluripotent stem cell (hPSC)-derived retinal organoids (ROs) can efficiently and reproducibly generate retinal neurons that have potential for use in cell replacement strategies [Capowski

Indexed as

Pluripotent Stem CellsRetinaAnimalsCell DifferentiationHumansOrganoidsReactive Oxygen SpeciesRetinal Ganglion CellsReactive Oxygen Specieshuman pluripotent stem cellsphotoreceptorsretinal organoidsynapsestrans-synaptic tracing

Identifiers

PMID36598946
PMCPMC9926218
OpenAlexW4313484955

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.