Evidence map›Paper›PMID 36598934›Full record

ArticleChemical research in toxicology2023

Chlorpyrifos Oxon Activates Glutamate and Lysine for Protein Cross-linking.

Diego Muñoz-Torrero, Lawrence M Schopfer, Oksana Lockridge

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical research in toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Diego Muñoz-TorreroLaboratory of Medicinal Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona, Barcelona 08028, Spain.ORCID 0000-0002-8140-8555
Lawrence M SchopferUniversity of Nebraska Medical Center, Omaha, Nebraska 68198, United States.ORCID 0000-0002-1785-9247
Oksana LockridgeUniversity of Nebraska Medical Center, Omaha, Nebraska 68198, United States.ORCID 0000-0002-8345-3640
University of Nebraska Medical Center · USUniversitat de Barcelona · ES

Funding

UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI James Eudy · 1985 to 2026
$55.0M
NCI NIH HHS P30 CA036727
6 · The paper itself

Abstract

Chronic low-dose exposure to organophosphorus (OP) toxicants is correlated with an increase in the risk of impaired cognition and neurodegenerative diseases. A mechanism to explain this relationship is needed. We suggest that the formation of organophosphate-induced high-molecular-weight protein aggregates that disrupt cell function may be the missing link. It has been demonstrated that such aggregation can be promoted by OP-labeled lysine. Alternatively, OP-labeled glutamate may be the initiator. To test this hypothesis, we treated MAP-rich tubulin

Indexed as

ChlorpyrifosLysineGlutamic AcidHumansOrganophosphatesProtein AggregatesProteinsChlorpyrifosdiethyl phosphateGlutamic AcidLysineO,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphateOrganophosphatesProtein AggregatesProteins

Identifiers

PMID36598934
PMCPMC9846825
OpenAlexW4313488761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.