Evidence map›Paper›PMID 36598820›Full record

ArticleJournal of natural products2023

Synthesis and Comprehensive in Vivo Activity Profiling of Olean-12-en-28-ol, 3β-Pentacosanoate in Experimental Autoimmune Encephalomyelitis: A Natural Remyelinating and Anti-Inflammatory Agent.

Halil Senol, Ozden Ozgun-Acar, Aydan Dağ, Ahmet Eken, Hüseyin Guner, Zaliha Gamze Aykut, Gulacti Topcu, Alaattin Sen

Open access · hybridAbstract read
In one paragraph

Article in Journal of natural products, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Halil SenolDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, 34093 Fatih, Istanbul, Turkey.
Ozden Ozgun-AcarSeed Breeding & Genetics Application Research Center, Pamukkale University, 20070 Denizli, Turkey.
Aydan DağDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, 34093 Fatih, Istanbul, Turkey.ORCID 0000-0002-1552-8030
Ahmet EkenDepartment of Basic Medical Sciences, Faculty of Medicine, Medical Biology Erciyes University, 38039 Kayseri, Turkey.
Hüseyin GunerDepartment of Molecular Biology and Genetics, Faculty of Life and Natural Sciences, University of Abdullah Gul 38080 Kayseri, Turkey.
Zaliha Gamze AykutLaboratory Animals Facility, Bilkent University, 06800 Ankara, Turkey.
Gulacti TopcuDepartment of Pharmacognosy & Phytochemistry, Faculty of Pharmacy, Bezmialem Vakif University, 34093 Fatih, Istanbul, Turkey.
Alaattin SenDepartment of Molecular Biology and Genetics, Faculty of Life and Natural Sciences, University of Abdullah Gul 38080 Kayseri, Turkey.ORCID 0000-0002-8444-376X
Bezmiâlem Vakıf Üniversitesi · TRPamukkale University · TRAbdullah Gül University · TRBilkent University · TRErciyes University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) treatment has received much attention, yet there is still no certain cure. We herein investigate the therapeutic effect of olean-12-en-28-ol, 3β-pentacosanoate (OPCA) on a preclinical model of MS. First, OPCA was synthesized semisynthetically and characterized. Then, the mice with MOG

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalAnimalsAnti-Inflammatory AgentsCytokinesHumansInflammationMiceMice, Inbred C57BLAnti-Inflammatory AgentsCytokines

Identifiers

PMID36598820
PMCPMC9887603
OpenAlexW4313482880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.