Evidence map›Paper›PMID 36598739›Full record

Trial reportJournal of thrombosis and thrombolysis2023

Thrombogenicity and endothelial progenitor cells function during Acute myocardial infarction - comparison of Prasugrel versus Ticagrelor.

Maya Wiessman, Mark Kheifets, Nili Schamroth Pravda, Dorit Leshem Lev, Eti Ziv, Ran Kornowski, Galia Spectre, Leor Perl

Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of thrombosis and thrombolysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Maya Wiessman *Department of Cardiology, Rabin Medical Center, Beilinson Campus, 39 Ze'ev Jabotinsky St, 4941492, Petach Tikva, Israel. mparyente@gmail.com.ORCID http://orcid.org/0000-0002-8044-7878
Mark Kheifets *Department of Cardiology, Rabin Medical Center, Beilinson Campus, 39 Ze'ev Jabotinsky St, 4941492, Petach Tikva, Israel.
Nili Schamroth PravdaDepartment of Cardiology, Rabin Medical Center, Beilinson Campus, 39 Ze'ev Jabotinsky St, 4941492, Petach Tikva, Israel.
Dorit Leshem LevThe Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Eti ZivThrombosis and Haemostasis Unit, Institute of Hematology, Rabin Medical Center, Beilinson Campus, Petah-Tikva, Israel.
Ran KornowskiDepartment of Cardiology, Rabin Medical Center, Beilinson Campus, 39 Ze'ev Jabotinsky St, 4941492, Petach Tikva, Israel.
Galia Spectre *The Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Leor Perl *Department of Cardiology, Rabin Medical Center, Beilinson Campus, 39 Ze'ev Jabotinsky St, 4941492, Petach Tikva, Israel.
Tel Aviv University · ILRabin Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThrombin generation (TG), platelet function and circulating endothelial progenitor cells (EPCs) have an important role in the pathophysiology of coronary artery disease (CAD). To date, the effect of novel P2Y

objectivesComparing the effects of prasugrel and ticagrelor on TG and EPCs in the acute phase of ST-segment elevation myocardial infarction (STEMI).

methodsSTEMI patients were randomized to either ticagrelor or prasugrel treatment. TG, platelet reactivity and EPCs were evaluated prior to P2Y

resultsBetween December 2018 - July 2021, 83 consecutive STEMI patients were randomized to ticagrelor (N = 42) or prasugrel (N = 41) treatment. No differences were observed at T0 for all measurements. P2Y

conclusionAmong STEMI patients, prasugrel as compared to ticagrelor was associated with more potent TG inhibition and improved EPCs count and function.

Indexed as

Endothelial Progenitor CellsMyocardial InfarctionPercutaneous Coronary InterventionST Elevation Myocardial InfarctionAdenosineHumansPlatelet Aggregation InhibitorsPrasugrel HydrochloridePurinergic P2Y Receptor AntagonistsThrombinTicagrelorTreatment OutcomeAdenosinePlatelet Aggregation InhibitorsPrasugrel HydrochloridePurinergic P2Y Receptor AntagonistsThrombinTicagrelorEndothelial progenitor cellsPrasugrelSTEMIThrombinTicagrelor

Identifiers

PMID36598739
PMCPMC9811044
OpenAlexW4313488558

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.