Evidence map›Paper›PMID 36598544›Full record

ArticleActa neurochirurgica2023

Spinal cord stimulation in non-reconstructable critical limb ischemia: a retrospective study of 71 cases.

G S Piedade, J Vesper, D Reichstein, A K Dauphin, S Damirchi

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neurochirurgica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06480786 (Spinal Cord Stimulation for Patients With Painful Diabetic Neuropathy and Peripheral Arterial Disease), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06480786 narecruitingnot on this mapstarted 2024, after this paper: background citation

Spinal Cord Stimulation for Patients With Painful Diabetic Neuropathy and Peripheral Arterial Disease: Mechanistic Insights From a Single-center, Randomized, Blinded, Sham-controlled Cross-over Proof-of-concept Trial

TypeinterventionalSponsorUniversity of NebraskaRan2024 to 2027Enrolled15ConditionsPeripheral Arterial Disease, Painful Diabetic Neuropathy, Diabetes Mellitus, Type 2, Chronic PainArmsSpinal cord stimulation, Sham stimulation
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Spinal Cord Stimulation for Intractable Chronic Limb Ischemia: A Narrative Review.Journal of cardiovascular development and disease · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

G S PiedadeDepartment of Neurosurgery, Helios Universitätsklinikum Wuppertal, Universität Witten/Herdecke, Heusnerstr. 40, 42283, Wuppertal, Germany. guipiedade@gmail.com.ORCID 0000-0002-1907-4558
J VesperDepartment of Functional Neurosurgery and Stereotaxy, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany. Jan.vesper@med.uni-duesseldorf.de.
D ReichsteinDepartment of Vascular Surgery, Evangelisches Krankenhaus Herne, Herne, Germany.
A K DauphinDepartment of Vascular Surgery, Evangelisches Krankenhaus Herne, Herne, Germany.
S DamirchiDepartment of Vascular Surgery, Evangelisches Krankenhaus Herne, Herne, Germany.
Heinrich Heine University Düsseldorf · DEUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpinal cord stimulation (SCS) is a therapeutic option for patients with a peripheral arterial disease with critical limb ischemia (CLI) and consequent ischemic rest pain. Neuromodulation is chosen when vascular reconstruction is not possible or failed. Data about the effect of SCS over limb salvage rates are dissonant.

methodWe report on a retrospective cohort of CLI patients who were implanted with SCS systems between July 2010 and December 2013 in a single center. Major amputation, postoperative complications, and death were recorded.

resultsSeventy-two CLI patients underwent SCS implantation, with 35 of them classified as non-reconstructable and 37 with previous but failed or only partially successful vascular procedures. A total of 21 subjects were at Fontaine's stage III (29.2%), and the remaining 51 were at stage IV (70.8%). In total, 26.4% of the patients had diabetes (n = 19), two of them at Fontaine's stage III. The mean follow-up was 17.1 ± 10.5 months. At the last follow-up, 59.2% of all patients (42/71), 85.7% of Fontaine's stage III (18/21), 48.0% of Fontaine's stage IV (24/50), and 52.6% of diabetic patients (10/19) were alive without major amputation. The probability of limb survival at 12 months was 72% for all patients, 94% for Fontaine's stage III, 62% for Fontaine's stage IV, and 61% for diabetic patients. The probability of survival at 12 months for patients who underwent major limb amputation (n = 25) was 86% with a mean survival time of 31.03 ± 4.63 months.

conclusionsNon-reconstructable CLI patients treated with SCS can achieve meaningful clinical outcomes with few procedure-related complications. The therapy may be more beneficial in patients classified as Fontaine's Stage III.

Indexed as

Diabetes MellitusSpinal Cord StimulationChronic Limb-Threatening IschemiaHumansIschemiaLegRetrospective StudiesSpinal CordTreatment OutcomeCritical limb ischemiaNeuromodulationPeripheral arterial diseaseSpinal cord stimulation

Identifiers

PMID36598544
PMCPMC10068652
OpenAlexW4313488498

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.