Evidence map›Paper›PMID 36598265›Full record

ArticleAntimicrobial agents and chemotherapy2023

Going Back in Time: Increasing Penicillin Susceptibility among Methicillin-Susceptible Staphylococcus aureus Osteoarticular Infections in Children.

J Chase McNeil, Lauren M Sommer, Jesus G Vallejo, Mary Boyle, Kristina G Hulten, Sheldon L Kaplan, Stephanie A Fritz

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Variability and interpretability of benzylpenicillin inhibition zone edges in Staphylococcus aureus - a multi-center study in Austria.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  2. Genetic Variation in theAntibiotics (Basel, Switzerland) · 2025
    Article
  3. Penicillin susceptibility amongMicrobiology spectrum · 2024
    Article
  4. Measuring beta-lactam minimum inhibitory concentrations inJournal of clinical microbiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

J Chase McNeilDepartment of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-0232-7491
Lauren M SommerDepartment of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.
Jesus G VallejoDepartment of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.
Mary BoyleDepartment of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Kristina G HultenDepartment of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.
Sheldon L KaplanDepartment of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.
Stephanie A FritzDepartment of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4M
Role of Staphylococcus aureus alpha-hemolysin in diseaseR01AI097434 · NIAID · WASHINGTON UNIVERSITY · PI BUBECK WARDENBURG, JULIANE · 2012 to 2021
$4.0M
Integrating Personal and Household Environmental Hygiene Measures to Prevent Methicillin-Resistant Staphylococcus aureus InfectionR01HS024269 · AHRQ · WASHINGTON UNIVERSITY · PI FRITZ, STEPHANIE ANN · 2015 to 2019
$2.5M
EPIDEMIOLOGY AND ERADICATION OF MRSA IN HOUSEHOLDS WITH CHILDRENR01HS021736 · AHRQ · WASHINGTON UNIVERSITY · PI FRITZ, STEPHANIE ANN · 2012 to 2016
$2.5M
The Impact of Healthcare Exposure on Colonization with Antiseptic Tolerant Staphylococci in ChildrenR01HS026896 · AHRQ · BAYLOR COLLEGE OF MEDICINE · PI MCNEIL, JONATHON CHASE · 2019 to 2023
$2.4M
Staphylococcus aureus resistance to topical antimicrobial agents in childrenK23AI099159 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MCNEIL, JONATHON CHASE · 2013 to 2017
$821k
TRANSMISSION DYNAMICS OF CA-MRSA AMONG HOUSEHOLD MEMBERS AND THE HOME ENVIRONMENTK23AI091690 · NIAID · WASHINGTON UNIVERSITY · PI FRITZ, STEPHANIE ANN · 2011 to 2014
$506k
AHRQ HHS R01 HS021736AHRQ HHS R01 HS024269AHRQ HHS R01 HS026896NCATS NIH HHS UL1 TR002345NCRR NIH HHS UL1 RR024992NIAID NIH HHS K23 AI091690NIAID NIH HHS K23 AI099159NIAID NIH HHS R01 AI097434
6 · The paper itself

Abstract

In the late 1940s to 1950s, Staphylococcus aureus isolates first-gained resistance to penicillin. Recently, some centers have described an increase in the proportion of methicillin susceptible S. aureus (MSSA) which are also susceptible to penicillin (PSSA). There are little data on the frequency of PSSA infections in children. We investigated the prevalence of penicillin susceptibility among pediatric MSSA acute hematogenous osteoarticular infection (OAI) isolates. MSSA OAI isolates were obtained through surveillance studies at Texas Children's and St. Louis Children's Hospitals from January 2011 to December 2019. All isolates underwent PCR for

Indexed as

Methicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsAnti-Bacterial AgentsChildChild, PreschoolHumansMethicillinMicrobial Sensitivity TestsMultilocus Sequence TypingPenicillinsStaphylococcus aureusAnti-Bacterial AgentsMethicillinPenicillinschildrenMSSAosteomyelitispediatricspenicillin

Identifiers

PMID36598265
PMCPMC9872685

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.