Evidence map›Paper›PMID 36598223›Full record

ArticleMicrobiology spectrum2023

Fatty Acyl Coenzyme A Synthetase Fat1p Regulates Vacuolar Structure and Stationary-Phase Lipophagy in Saccharomyces cerevisiae.

Fan Qiu, Na Kang, Jinling Tan, Sisi Yan, Leiying Lin, Lipeng Cai, Joel M Goodman, Qiang Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fan QiuSchool of Biomedical Sciences, Hunan University, Changsha, Hunan, China.
Na KangSchool of Biomedical Sciences, Hunan University, Changsha, Hunan, China.
Jinling TanSchool of Biomedical Sciences, Hunan University, Changsha, Hunan, China.
Sisi YanSchool of Biomedical Sciences, Hunan University, Changsha, Hunan, China.
Leiying LinSchool of Biomedical Sciences, Hunan University, Changsha, Hunan, China.
Lipeng CaiSchool of Biomedical Sciences, Hunan University, Changsha, Hunan, China.
Joel M GoodmanDepartment of Pharmacology, University of Texas Southwestern Medical School, Dallas, Texas, USA.
Qiang GaoSchool of Biomedical Sciences, Hunan University, Changsha, Hunan, China.ORCID 0000-0002-0562-2998

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During yeast stationary phase, a single spherical vacuole (lysosome) is created by the fusion of several small ones. Moreover, the vacuolar membrane is reconstructed into two distinct microdomains. Little is known, however, about how cells maintain vacuolar shape or regulate their microdomains. Here, we show that Fat1p, a fatty acyl coenzyme A (acyl-CoA) synthetase and fatty acid transporter, and not the synthetases Faa1p and Faa4p, is essential for vacuolar shape preservation, the development of vacuolar microdomains, and cell survival in stationary phase of the yeast Saccharomyces cerevisiae. Furthermore, Fat1p negatively regulates general autophagy in both log- and stationary-phase cells. In contrast, Fat1p promotes lipophagy, as the absence of

Indexed as

Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAutophagyCoenzyme A LigasesFatty AcidsFatty Acid Transport ProteinsVacuolesCoenzyme A LigasesFAT1 protein, S cerevisiaeFatty AcidsFatty Acid Transport ProteinsSaccharomyces cerevisiae Proteinslipophagystationary phaseunsaturated fatty acidvacuole microdomainsvacuole morphology

Identifiers

PMID36598223
PMCPMC9927365

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.