Evidence map›Paper›PMID 36598192›Full record

ArticlemBio2023

The C-Type Lectin Receptor Dectin-2 Is a Receptor for Aspergillus fumigatus Galactomannan.

Jennifer L Reedy, Arianne J Crossen, Paige E Negoro, Hannah Brown Harding, Rebecca A Ward, Diego A Vargas-Blanco, Kyle D Timmer, Christopher M Reardon, Kyle J Basham, Michael K Mansour and 4 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Non-viableMicrobiology spectrum · 2026
    Article
  4. Review
  5. Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  6. Recent developments inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Interplay of Cytokines and Chemokines in Aspergillosis.Journal of fungi (Basel, Switzerland) · 2024
    Review
  13. Article
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Jennifer L ReedyDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Arianne J CrossenDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Paige E NegoroDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Hannah Brown HardingDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Rebecca A WardDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Diego A Vargas-BlancoDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Kyle D TimmerDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Christopher M ReardonDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Kyle J BashamDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Michael K MansourDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Marcel WüthrichDepartment of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, Wisconsin, USA.
Thierry FontaineInstitut Pasteur, Université de Paris, INRAE, USC2019, Unité Biologie et Pathogénicité Fongiques, Paris, France.
Jean-Paul LatgéInstitute of Molecular Biology and Biotechnology (IMBBFORTH), University of Crete, Heraklion, Greece.
Jatin M VyasDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-9985-9565
Massachusetts General Hospital · USHarvard University · USInstitut Pasteur · FRUniversity of Crete · GRUW Health University Hospital · US

Funding

PROTECTIVE IMMUNE RESPONSES TO BLASTOMYCES DERMATITIDISR01AI040996 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN, WUETHRICH, MARCEL · 1997 to 2023
$10.4M
Harvard Clinical and Translational Science CenterKL2TR001100 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$8.5M
Control of Type I Interferon Production in Response to Candida albicansR01AI150181 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Jatin M Vyas · 2020 to 2026
$5.4M
The Functional Role of the Tetraspanin CD82/Kai1 in Fungal Innate ImmunityR01AI136529 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2018 to 2022
$2.7M
Innate Immune Response to Aspergillus fumigatus Cell Wall CarbohydratesK08AI141755 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI REEDY, JENNIFER LYNNE · 2019 to 2022
$799k
Host Responses to Coccidioides by Human Airway EpitheliumR21AI152499 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2022 to 2023
$462k
NCATS NIH HHS KL2 TR001100NIAID NIH HHS K08 AI141755NIAID NIH HHS R01 AI040996NIAID NIH HHS R01 AI136529NIAID NIH HHS R01 AI150181NIAID NIH HHS R21 AI152499
6 · The paper itself

Abstract

Aspergillus fumigatus is a ubiquitous environmental mold that causes significant mortality particularly among immunocompromised patients. The detection of the

Indexed as

Aspergillus fumigatusMannansAnimalsGalactoseHumansLectins, C-TypeMammalsMicedectin-2, mousegalactomannanGalactoseLectins, C-TypeMannansAspergillus fumigatusfungihost-pathogen interactionsimmune mechanismsinnate immunitymycology

Identifiers

PMID36598192
PMCPMC9973300
OpenAlexW4313488035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.