Evidence map›Paper›PMID 36598186›Full record

ArticleACS nano2023

Porous Silicon Nanocarriers Boost the Immunomodulation of Mitochondria-Targeted Bovine Serum Albumins on Macrophage Polarization.

Jialiang Li, Jiqiang Fan, Yan Gao, Shuodan Huang, Di Huang, Jiachen Li, Xiaoyu Wang, Hélder A Santos, Pingping Shen, Bing Xia

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Jialiang LiCollege of Science, Nanjing Forestry University, Nanjing210037, China.
Jiqiang FanState Key Laboratory of Pharmaceutical Biotechnology and The Comprehensive Cancer Center, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing University, Nanjing210023, China.
Yan GaoCollege of Science, Nanjing Forestry University, Nanjing210037, China.
Shuodan HuangCollege of Science, Nanjing Forestry University, Nanjing210037, China.
Di HuangCollege of Science, Nanjing Forestry University, Nanjing210037, China.
Jiachen LiDepartment of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AVGroningen, The Netherlands.
Xiaoyu WangCollege of Science, Nanjing Forestry University, Nanjing210037, China.
Hélder A SantosDepartment of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AVGroningen, The Netherlands.ORCID 0000-0001-7850-6309
Pingping ShenDepartment of Geriatric Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou325027, China.
Bing XiaCollege of Science, Nanjing Forestry University, Nanjing210037, China.ORCID 0000-0002-1637-7908
Nanjing Forestry University · CNUniversity Medical Center Groningen · NLNanjing Drum Tower Hospital · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of nanosystems with intrinsic immunomodulatory effects on macrophage polarization is important for the macrophage-targeted immunotherapy. Here, mitochondria-targeted bovine serum albumins (BSAs) via the conjugation of fluorescent, lipophilic, and cationic rhodamine 110 molecules can efficiently enhance the gene expression of the proinflammatory phenotype of macrophages and correspondingly inhibit the gene expression of their anti-inflammatory phenotype. On this basis, porous silicon nanocarriers can further boost the immunomodulation of these mitochondria-targeted BSAs

Indexed as

albumin proteinsmacrophage polarizationmitochondrial targetingporous silicon nanoparticlesreactive oxygen species (ROS)signaling transduction pathways

Identifiers

PMID36598186
PMCPMC9878978
OpenAlexW4313488292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.