Evidence map›Paper›PMID 36598109›Full record

ArticleGlia2023

Genesis of a functional astrocyte syncytium in the developing mouse hippocampus.

Shiying Zhong, Conrad M Kiyoshi, Yixing Du, Wei Wang, Yumeng Luo, Xiao Wu, Anne T Taylor, Baofeng Ma, Sydney Aten, Xueyuan Liu and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Glia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Membrane voltage multistability in coupled glial cells.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Astrocyte gap junctions and KFrontiers in cellular neuroscience · 2025
    Article
  9. Astrocyte Syncytium-A Biopower Grid System in the Brain.Journal of integrative neuroscience · 2024
    Article
  10. Article
  11. CaFrontiers in cellular neuroscience · 2023
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Shiying ZhongDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Conrad M KiyoshiDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Yixing DuDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Wei WangDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Yumeng LuoDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Xiao WuDepartment of Neurology, Wuhan First Hospital, Wuhan, China.
Anne T TaylorDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Baofeng MaDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Sydney AtenDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Xueyuan LiuDepartment of Neurology, Shanghai 10th Hospital of Tongji University, School of Medicine, Shanghai, China.
Min ZhouDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.ORCID 0000-0001-6249-2977
The Ohio State University Wexner Medical Center · USTongji University · CNWuhan No.1 Hospital · CN

Funding

Functional plasticity of astrocyte syncytial networkR01NS116059 · NINDS · OHIO STATE UNIVERSITY · PI ZHOU, MIN · 2020 to 2024
$1.9M
Involvement of astrocytic two-pore domain K+ channels in ischemic pathologyR01NS062784 · NINDS · ORDWAY RESEARCH INSTITUTE, INC. · PI ZHOU, MIN · 2010 to 2014
$1.7M
Astrocyte function at syncytial system levelsR56NS097672 · NINDS · OHIO STATE UNIVERSITY · PI ZHOU, MIN · 2016 to 2016
$385k
NINDS NIH HHS R01 NS062784NINDS NIH HHS R01 NS116059NINDS NIH HHS R56 NS097672
6 · The paper itself

Abstract

Astrocytes are increasingly shown to operate as an isopotential syncytium in brain function. Protoplasmic astrocytes acquire this ability to functionally go beyond the single-cell level by evolving into a spongiform morphology, cytoplasmically connecting into a syncytium, and expressing a high density of K

Indexed as

AstrocytesHippocampusAnimalsCA1 Region, HippocampalGap JunctionsMembrane PotentialsMiceastrocyteselectrical couplinggap junctionsK+ conductancesyncytial isopotentiality

Identifiers

PMID36598109
PMCPMC10777263
OpenAlexW4313489162

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.