Evidence map›Paper›PMID 36597631›Full record

ArticleNeurospine2022

The Effect of Subsidence on Segmental and Global Lordosis at Long-term Follow-up After Anterior Cervical Discectomy and Fusion.

Akiro H Duey, Christopher Gonzalez, Eric A Geng, Pierce J Ferriter, Ashley M Rosenberg, Ula N Isleem, Bashar Zaidat, Paul M Al-Attar, Jonathan S Markowitz, Jun S Kim and 1 more

Abstract read
In one paragraph

Article in Neurospine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Comparative analysis of novel vertebral bone quality score variants for predicting cage subsidence following single-level anterior cervical discectomy and fusion: a retrospective cohort study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  2. Single-level anterior cervical discectomy and fusion for degenerative disc disease: a retrospective, two-center comparative analysis of stand-alone cage versus cage-plate constructs.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Akiro H DueyDepartment of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Christopher GonzalezDepartment of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Eric A GengDepartment of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Pierce J FerriterDepartment of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ashley M RosenbergDepartment of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ula N IsleemDepartment of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bashar ZaidatDepartment of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Paul M Al-AttarDepartment of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jonathan S MarkowitzDepartment of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jun S KimDepartment of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Samuel K ChoDepartment of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSubsidence following anterior cervical discectomy and fusion (ACDF) may lead to disruptions of cervical alignment and lordosis. The purpose of this study was to evaluate the effect of subsidence on segmental, regional, and global lordosis.

methodsThis was a retrospective cohort study performed between 2016-2021 at a single institution. All measurements were performed using lateral cervical radiographs at the immediate postoperative period and at final follow-up greater than 6 months after surgery. Associations between subsidence and segmental lordosis, total fused lordosis, C2-7 lordosis, and cervical sagittal vertical alignment change were determined using Pearson correlation and multivariate logistic regression analyses.

resultsOne hundred thirty-one patients and 244 levels were included in the study. There were 41 one-level fusions, 67 two-level fusions, and 23 three-level fusions. The median follow-up time was 366 days (interquartile range, 239-566 days). Segmental subsidence was significantly negatively associated with segmental lordosis change in the Pearson (r = -0.154, p = 0.016) and multivariate analyses (beta = -3.78; 95% confidence interval, -7.15 to -0.42; p = 0.028) but no associations between segmental or total fused subsidence and any other measures of cervical alignment were observed.

conclusionWe found that subsidence is associated with segmental lordosis loss 6 months following ACDF. Surgeons should minimize subsidence to prevent long-term clinical symptoms associated with poor cervical alignment.

Indexed as

Cervical vertebraeDiskectomyIntervertebral discLordosisSpinal fusionVertebral body

Identifiers

PMID36597631
PMCPMC9816598

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.