Evidence map›Paper›PMID 36597547›Full record

ArticleResearch square2022

The mRNA vaccine BNT162b2 demonstrates impaired T

Byron Brook, Benoit Fatou, Abhinav Kumar Checkervarty, Soumik Barman, Cali Sweitzer, Anna-Nicole Bosco, Amy C Sherman, Lindsey R Baden, Elena Morrocchi, Guzman Sanchez-Schmitz and 12 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 5 institutions in 3 countries.

Byron BrookPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0003-3184-8285
Benoit FatouDepartment of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Abhinav Kumar CheckervartyPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-1032-9198
Soumik BarmanPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Cali SweitzerPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Anna-Nicole BoscoPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Amy C ShermanPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Lindsey R BadenDepartment of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Elena MorrocchiPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Guzman Sanchez-SchmitzPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Paolo PalmaBambino Gesù Children's Hospital, Rome, Italy.
Etsuro NanishiPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-9957-7162
Timothy R O'MearaPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-3651-5167
Marisa E McGrathCenter for Pathogen Research, Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, MD, USA.
Matthew B FriemanCenter for Pathogen Research, Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-0107-0775
Dheeraj SoniPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-5555-2051
Simon D van HarenPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Al OzonoffPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0003-4233-5899
Joann Diray-ArcePrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Hanno SteenPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
David J DowlingPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0003-1095-6156
Ofer LevyPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Boston Children's Hospital · USBrigham and Women's Hospital · USUniversity of Maryland, Baltimore · USBroad Institute · USUniversity of Rome Tor Vergata · IT

Funding

Transcriptomics to define biomarkers of neonatal vaccine immunogenicityU19AI118608 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LEVY, OFER · 2017 to 2021
$24.7M
Small-molecule adjuvants to enhance the efficacy of flu vaccines in newborns and the elderly75N93019C00044 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LEVY, OFER · 2019 to 2023
$11.0M
Leveraging immunostimulatory pathways that enhance BCG vaccination for the rational design of synthetic neonatal vaccine formulationsR21AI137932 · NIAID · NORTHWESTERN UNIVERSITY · PI DOWLING, DAVID JAMES, SCOTT, EVAN ALEXANDER · 2019 to 2020
$468k
NIAID NIH HHS 75N93019C00044NIAID NIH HHS HHSN272201400052CNIAID NIH HHS HHSN272201800047CNIAID NIH HHS R21 AI137932NIAID NIH HHS U19 AI118608
6 · The paper itself

Abstract

mRNA vaccines have been key to addressing the SARS-CoV-2 pandemic but have impaired immunogenicity and durability in vulnerable older populations. We evaluated the mRNA vaccine BNT162b2 in human

Identifiers

PMID36597547
PMCPMC9810224
OpenAlexW4312102317

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.