Evidence map›Paper›PMID 36597447›Full record

ArticleAmerican journal of ophthalmology case reports2023

Acute posterior multifocal placoid pigment epitheliopathy following COVID-19 infection.

Nathan A Fischer, Robert C Wann, Jason N Crosson

Open access · goldAbstract readCase Reports
In one paragraph

Article in American journal of ophthalmology case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Presumed Ocular tuberculosis masquerading as autoimmune retinopathy.American journal of ophthalmology case reports · 2025
    Article
  2. Article
  3. Atypical presentation of acute macular neuroretinopathy: a case description.Quantitative imaging in medicine and surgery · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nathan A FischerDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham 1720 University Boulevard Birmingham, AL 35294-0099, USA.
Robert C WannDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham 1720 University Boulevard Birmingham, AL 35294-0099, USA.
Jason N CrossonDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham 1720 University Boulevard Birmingham, AL 35294-0099, USA.
University of Alabama at Birmingham · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To report a case of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) following COVID-19 infection. Observations: A 17-year-old female developed central scotomas and photopsias two weeks after SARS-CoV-2 diagnosis with polymerase chain reaction studies. She presented with poor visual acuity of 3/60 on the Feinbloom eye chart in the left eye. Dilated examination and multi-modal retinal imaging were consistent with the diagnosis of APMPPE, with noteworthy subretinal fluid. The patient was treated with an oral prednisone taper starting at 60mg with rapid resolution in subretinal fluid and improvement of visual acuity. Five weeks after presentation, visual acuity improved to 20/20 OU with complete resolution of the creamy white choroidal lesions and subretinal fluid. Conclusion: There is a growing body of literature reporting the ocular manifestations of COVID-19. Rarely inflammation of the retina or choroid have been associated with the infection. To the best of our knowledge, there are no prior reports that describe the clinical course or visual outcome in a patient with APMPEE associated with recent COVID-19 infection. Accordingly, we are not aware of any other reports that describe the treatment of APMPEE associated with COVID-19 with corticosteroids. The mechanism linking COVID-19 infection to inflammatory ocular disorders in unclear and likely multi-factorial.

Indexed as

Acute posterior multifocal placoid pigment epitheliopathyCoronavirus disease 2019COVID-19Multi-modal retinal imaging

Identifiers

PMID36597447
PMCPMC9800013
OpenAlexW4313400471

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.