Evidence map›Paper›PMID 36597409›Full record

ArticleThe Journal of international medical research2023

Exosomal miR-202 derived from leukorrhea as a potential biomarker for endometriosis.

Li Zheng, Dai Fei Sun, Yanyan Tong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Review
  7. Identification of Key miRNAs in Endometriosis.MicroRNA (Shariqah, United Arab Emirates) · 2025
    Article
  8. Article
  9. Review
  10. The role of small extracellular vesicle-miRNAs in endometriosis.Human reproduction (Oxford, England) · 2023
    Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Li ZhengDepartment of Obstetrics and Gynaecology, Ningbo Women and Children's Hospital, Zhejiang, China.
Dai Fei SunDepartment of Obstetrics and Gynaecology, Ningbo Women and Children's Hospital, Zhejiang, China.
Yanyan TongDepartment of Obstetrics and Gynaecology, Ningbo Women and Children's Hospital, Zhejiang, China.ORCID 0000-0002-4537-2786
Northwest Women's and Children's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveEndometriosis (EMS) is a chronic gynecological disorder with an urgent need of a reliable non-invasive diagnostic strategy. Recently, there has been increasing interest in using the contents of exosomes, especially exosomal microRNAs (miRNAs), as potential biomarkers for various types of diseases. In this study, we assessed the differentially expressed miRNAs in exosomes derived from primary normal and ectopic endometrial cells.

methodsWe used miRNA microarray analysis to identify differentially expressed exosomal miRNAs. Among the selected exosomal miRNAs, we focused on hsa-miR-202-3p and hsa-miR-202-5p and validated their expression levels using quantitative reverse transcription polymerase chain reaction analysis. We then further examined their expression in exosomes derived from vaginal discharge (leukorrhea) from patients with EMS and the negative control group.

resultsThe data show that hsa-miR-202-3p and hsa-miR-202-5p were expressed significantly higher in leukorrhea-derived exosomes from EMS patients compared with the negative controls.

conclusionTaken together, our results suggest that leukorrhea-derived exosomal hsa-miR-202 could serve as a potential useful biomarker for diagnosing EMS.

Indexed as

EndometriosisExosomesLeukorrheaMicroRNAsBiomarkersFemaleHumansBiomarkersMicroRNAsMIRN202 microRNA, humanbiomarkerEndometriosisexosomemicroarraymiR-202quantitative reverse transcription polymerase chain reactionvaginal discharge

Identifiers

PMID36597409
PMCPMC9830089
OpenAlexW4313494641

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.