Evidence map›Paper›PMID 36597256›Full record

ReviewWIREs mechanisms of disease

Intracellular and microenvironmental regulation of mitochondrial membrane potential in cancer cells.

Hydari Masuma Begum, Keyue Shen

Open access · hybridAbstract readReview
In one paragraph

Review in WIREs mechanisms of disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Mitochondria-Damaging Self-Reporting Probe for Cancer Therapy.Angewandte Chemie (International ed. in English) · 2026
    Article
  4. QSAR modeling and in vitro studies of the selective action of triphenylphosphonium salts as anticancer agents against the rhabdomyosarcoma cell line.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Article
  5. Article
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  7. Article
  8. Article
  9. Article
  10. Study ofWorld journal of biological chemistry · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Saga of MCL1 inhibitors in multiple myeloma.Biochemical pharmacology · 2026
    Review
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hydari Masuma BegumAlfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA.
Keyue ShenAlfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA.ORCID 0000-0001-9605-1635
University of Southern California · US

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4M
(PQ5) Microenvironmental Regulation of Mitochondrial Heterogeneity in Cancer MetastasisR01CA220012 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHEN, KEYUE · 2019 to 2023
$2.2M
Artificial Stromal Cell for Hematopoietic Stem Cell ExpansionR21EB024748 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHEN, KEYUE · 2017 to 2019
$637k
NCI NIH HHS P30 CA014089NCI NIH HHS R01 CA220012NIBIB NIH HHS R21 EB024748
6 · The paper itself

Abstract

Cancer cells have an abnormally high mitochondrial membrane potential (ΔΨ

Indexed as

NeoplasmsHumansMembrane Potential, MitochondrialSignal TransductionTumor Microenvironmentintracellular signalingmetastasismitochondrial membrane potential (ΔΨm)tumor microenvironment

Identifiers

PMID36597256
PMCPMC10176868
OpenAlexW4313546400

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.