Evidence map›Paper›PMID 36597186›Full record

ArticlePhysiological reports2023

Extracellular vesicles and insulin-mediated vascular function in metabolic syndrome.

Tristan J Ragland, Emily M Heiston, Anna Ballantyne, Nathan R Stewart, Sabrina La Salvia, Luca Musante, Melissa A Luse, Brant E Isakson, Uta Erdbrügger, Steven K Malin

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Physiological reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06546085 (Extracellular Vesicles, Insulin Action, and Exercise on Vascular Function in Type 2 Diabetes), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06546085 narecruitingnot on this mapstarted 2025, after this paper: background citation

Extracellular Vesicles, Insulin Action, and Exercise on Vascular Function in Type 2 Diabetes

TypeinterventionalSponsorRutgers, The State University of New JerseyRan2025 to 2029Enrolled60ConditionsType 2 Diabetes, ObesityArmsExercise
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Tristan J RaglandDepartment of Kinesiology & Health, Rutgers University, New Brunswick, New Jersey, USA.
Emily M HeistonDepartment of Internal Medicine, Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Anna BallantyneDepartment of Kinesiology, University of Virginia, Charlottesville, Virginia, USA.
Nathan R StewartDepartment of Kinesiology & Health, Rutgers University, New Brunswick, New Jersey, USA.
Sabrina La SalviaCardiovascular Research Institute, Mount Sinai, New York, New York, USA.
Luca MusanteSchool of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Melissa A LuseRobert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Brant E IsaksonRobert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Uta ErdbrüggerDivision of Nephrology, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Steven K MalinDepartment of Kinesiology & Health, Rutgers University, New Brunswick, New Jersey, USA.ORCID 0000-0002-7360-6711
University of Virginia · USRutgers, The State University of New Jersey · USMount Sinai Hospital · USUniversity of Pennsylvania · USVirginia Commonwealth University · US

Funding

Role of Pannexins in Vascular Smooth Muscle CellsP01HL120840 · NHLBI · UNIVERSITY OF VIRGINIA · PI BAYLISS, DOUGLAS A., RAVICHANDRAN, KODI S · 2014 to 2023
$24.0M
Exercise Dose and Metformin for Vascular Health in Adults with Metabolic SyndromeR01HL130296 · NHLBI · UNIVERSITY OF VIRGINIA · PI MALIN, STEVEN K · 2017 to 2021
$3.7M
Multi-Disciplinary Training Program in Translational Cardiovascular ResearchT32HL149645 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Lauren Ashley Cowart, William Gregory Hundley · 2020 to 2026
$2.2M
NHLBI NIH HHS P01 HL120840NHLBI NIH HHS R01 HL130296
6 · The paper itself

Abstract

Metabolic Syndrome (MetS) raises cardiovascular disease risk. Extracellular vesicles (EVs) have emerged as important mediators of insulin sensitivity, although few studies on vascular function exist in humans. We determined the effect of insulin on EVs in relation to vascular function. Adults with MetS (n = 51, n = 9 M, 54.8 ± 1.0 years, 36.4 ± 0.7 kg/m

Indexed as

Extracellular VesiclesInsulin ResistanceMetabolic SyndromeAdultAnimalsCross-Sectional StudiesHumansInsulinLeadMiceObesityInsulinLeadaugmentation indexinflammationinsulin resistanceobesitypulse wave analysisvasodilation

Identifiers

PMID36597186
PMCPMC9810789
OpenAlexW4313545877

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.