Evidence map›Paper›PMID 36597143›Full record

ArticleEye and vision (London, England)2023

Regional differences of the sclera in the ocular hypertensive rat model induced by circumlimbal suture.

Mingfang Xia, Endong Zhang, Fei Yao, Zhaohua Xia, Mingmin Zhou, Xufang Ran, Xiaobo Xia

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Eye and vision (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Mingfang XiaEye Center of Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Endong ZhangEye Center of Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Fei YaoEye Center of Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Zhaohua XiaEye Center of Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Mingmin ZhouEye Center of Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Xufang RanEye Center of Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Xiaobo XiaEye Center of Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. xbxia21@csu.edu.cn.ORCID http://orcid.org/0000-0002-6005-9667
Central South University · CN

Funding

Key R&D Plan of Hunan Province of China 2020SK2076The National Key Research and Development Program of China 2020YFC2008205The National Natural Science Foundation of China 81974134The National Natural Science Foundation of China 82171058
6 · The paper itself

Abstract

purposeTo describe the regional differences of the sclera in ocular hypertension (OHT) models with the inappropriate extension of the ocular axis.

methodsTo discover the regional differences of the sclera at the early stage, OHT models were established using circumlimbal suture (CS) or sclerosant injection (SI). Axial length (AL) was measured by ultrasound and magnetic resonance imaging. The glaucoma-associated distinction was determined by intraocular pressure (IOP) and retrograde tracing of retinal ganglion cells (RGCs). The central thickness of the ganglion cell complex (GCC) was measured by optical coherence tomography. RGCs and collagen fibrils were detected using a transmission electron microscope, furthermore, anti-alpha smooth muscle actin (αSMA) was determined in the early stage after the operation.

resultsCompared with the control group, the eyes in OHT models showed an increased IOP (P < 0.001 in the CS group, P = 0.001 in the SI group), growing AL (P = 0.026 in the CS group, P = 0.043 in the SI group), reduction of central RGCs (P < 0.001 in the CS group, P = 0.017 in the SI group), thinning central GCC (P < 0.001 in the CS group), and a distinctive expression of αSMA in the central sclera in the early 4-week stage after the operation (P = 0.002 in the CS group). Compared with the SI group, the eye in the CS group showed a significantly increased AL (7.1 ± 0.4 mm, P = 0.031), reduction of central RGCs (2121.1 ± 87.2 cells/mm

conclusionRegional differences of the sclera in the ocular hypertensive rat model induced by CS may provide a reference for further treatment of scleral-related eye disorders.

Indexed as

Animal modelsAxial lengthGlaucomaRetinal ganglion cellsSclera

Identifiers

PMID36597143
PMCPMC9811703
OpenAlexW4313455496

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.