Evidence map›Paper›PMID 36597123›Full record

SynthesisCritical care (London, England)2023

The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis.

Brigitta Fazzini, Tobias Märkl, Christos Costas, Manfred Blobner, Stefan J Schaller, John Prowle, Zudin Puthucheary, Henning Wackerhage

3 registry-linked trialsOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Critical care (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 184 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
184citing papers in PubMed, 12 pooled it
68.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06400316 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Preventing Muscle Wasting During Rheumatoid Arthritis Flares: A Randomised Controlled Trial

TypeinterventionalSponsorLeeds Beckett UniversityRan2024 to 2024Enrolled40ConditionsRheumatoid Arthritis, Muscle AtrophyArmsAmino Acid Supplement
NCT06697470 recruitingnot on this mapstarted 2024, after this paper: background citation

Cross-sectional Study on the Variation of Muscle Thickness and Subcutaneous Tissues by Ultrasound and Bioelectrical Impedance in Association with the Fluid Balance of Patients in Intensive Care

Typeobservational_patient_registrySponsorDr F DuprezRan2024 to 2024Enrolled40ConditionsWeakness Acquired in the ICU, Muscle Wasting, Edema, Fluid OverloadArmsUltrasound and Bioelectrical Impedance Analysis for Muscle Thickness and Fluid Balance Assessment Translation
NCT06949163 nacompletednot on this map

Effect of Enteral Polymeric Formulas (Commercial and Homemade Formula) on Muscle Mass in Adults With Trauma Brain Injury

TypeinterventionalSponsorHospital General "Dr. Miguel Silva" de MoreliaRan2023 to 2025Enrolled39ConditionsTBI Traumatic Brain Injury, Enteral Nutrition Therapy, Critical IllnessArmsHomemade formula, Commercial formula
3 · Its place in the literature

Who cites it

184 citing papers in PubMed, 12 syntheses or guidelines pooled it, 322 citations in OpenAlex.

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  8. Erythropoiesis-stimulating agents for preventing acute kidney injury.The Cochrane database of systematic reviews · 2024
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124 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Brigitta FazziniAdult Critical Care Unit, The Royal London Hospital, Barts Health NHS Trust, London, UK. brigitta.fazzini@nhs.net.ORCID 0000-0003-3569-1203
Tobias MärklExercise Biology Group, Department of Sports and Health Sciences, Technical University of Munich, Munich, Germany.
Christos CostasWilliam Harvey Research Institute, Queen Mary University of London, London, UK.
Manfred BlobnerTechnical University of Munich, School of Medicine, Department of Anesthesiology and Intensive Care, Munich, Germany.
Stefan J SchallerTechnical University of Munich, School of Medicine, Department of Anesthesiology and Intensive Care, Munich, Germany.ORCID 0000-0002-6683-9584
John ProwleAdult Critical Care Unit, The Royal London Hospital, Barts Health NHS Trust, London, UK.
Zudin Puthucheary *Adult Critical Care Unit, The Royal London Hospital, Barts Health NHS Trust, London, UK.
Henning Wackerhage *Exercise Biology Group, Department of Sports and Health Sciences, Technical University of Munich, Munich, Germany. henning.wackerhage@tum.de.
Queen Mary University of London · GBTechnical University of Munich · DEBarts Health NHS Trust · GBHumboldt-Universität zu Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with critical illness can lose more than 15% of muscle mass in one week, and this can have long-term detrimental effects. However, there is currently no synthesis of the data of intensive care unit (ICU) muscle wasting studies, so the true mean rate of muscle loss across all studies is unknown. The aim of this project was therefore to systematically synthetise data on the rate of muscle loss and to identify the methods used to measure muscle size and to synthetise data on the prevalence of ICU-acquired weakness in critically ill patients.

methodsWe conducted a systematic literature search of MEDLINE, PubMed, AMED, BNI, CINAHL, and EMCARE until January 2022 (International Prospective Register of Systematic Reviews [PROSPERO] registration: CRD420222989540. We included studies with at least 20 adult critically ill patients where the investigators measured a muscle mass-related variable at two time points during the ICU stay. We followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and assessed the study quality using the Newcastle-Ottawa Scale.

resultsFifty-two studies that included 3251 patients fulfilled the selection criteria. These studies investigated the rate of muscle wasting in 1773 (55%) patients and assessed ICU-acquired muscle weakness in 1478 (45%) patients. The methods used to assess muscle mass were ultrasound in 85% (n = 28/33) of the studies and computed tomography in the rest 15% (n = 5/33). During the first week of critical illness, patients lost every day -1.75% (95% CI -2.05, -1.45) of their rectus femoris thickness or -2.10% (95% CI -3.17, -1.02) of rectus femoris cross-sectional area. The overall prevalence of ICU-acquired weakness was 48% (95% CI 39%, 56%).

conclusionOn average, critically ill patients lose nearly 2% of skeletal muscle per day during the first week of ICU admission.

Indexed as

Critical IllnessIntensive Care UnitsAdultHumansMuscle, SkeletalMuscle WeaknessMuscular AtrophyCritical illnessICU-acquired weaknessICU-AWIntensive care unitMuscle atrophyMuscle wasting

Identifiers

PMID36597123
PMCPMC9808763
OpenAlexW4313522108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.