ArticleBMC geriatrics2023
Effects of frailty, geriatric syndromes, and comorbidity on mortality and quality of life in older adults with HIV.
Article in BMC geriatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03558438 (Spanish Cohort of Patients with HIV Infection Older Than 50 Years for the Study of Fragility and Physical Function), which is not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Spanish Cohort of Patients with HIV Infection Older Than 50 Years for the Study of Fragility and Physical Function
Who cites it
26 citing papers in PubMed, 34 citations in OpenAlex.
- HIV update for the non-HIV specialist and general physician.Clinical medicine (London, England) · 2026Review
- Positive Self-Perception of Aging and Quality of Life in People Living with HIV: The Role of Cultural Stereotype Internalization.Healthcare (Basel, Switzerland) · 2026Article
- Article
- Multidisciplinary Care for Older People With HIV: Optimizing Medication and Enhancing Quality of Life.Open forum infectious diseases · 2026Article
- Correlates of Poor Quality of Life Among Older People Living With HIV: A Cross-Sectional Analysis of the Tanzania HIV and Aging Cohort Study.Journal of the International AIDS Society · 2026Article
- Cardiovascular Disease Risk and Falls in Men and Women Living With and Without HIV in MACS/WIHS Combined Cohort Study.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- Provider, researcher, and community perspectives on comorbidities affecting the health-related quality of life of people living with HIV in Spain.BMC public health · 2026Article
- Modeled Health and Economic Burden of Frailty and Falls Among Adults With HIV.JAMA network open · 2026Article
- Sarcopenia, its components and fracture risk in people living with human immunodeficiency virus.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Influence of comorbidities, geriatric syndromes, and frailty on mortality risk by discharge destination in older adults after acute hospitalization: a nationwide cohort study.Frontiers in public health · 2026Article
- Noncommunicable chronic comorbidities, perceived social support, depression, and health-related quality of life among people with HIV: a structural equation modeling study.BMC public health · 2025Article
- Advancing integration in the approach to older adults with HIV: perspectives from geriatric and HIV specialists.BMC geriatrics · 2025Article
- Improving the care pathway for people living with HIV aged 70 years and older: the impact of geriatric screening in an infectious diseases unit (AUTO-HIV 70).BMC geriatrics · 2025Article
- Article
- Article
- Influence of antiretroviral therapy on frailty among people living with HIV.Scientific reports · 2025Observational
- Approaches to optimally target frailty screening among people with HIV in clinical care: findings from the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS).Journal of acquired immune deficiency syndromes (1999) · 2025Article
- Evaluation of the effects of thyroid functions on frailty in geriatric patients using the Edmonton, SOF and FRAIL Scales.BMC geriatrics · 2024Article
- Predicting Multiple Outcomes Associated with Frailty based on Imbalanced Multi-label Classification.Journal of healthcare informatics research · 2024Article
- Cluster-Based Multinomial Logistic Regression Model for Health-Related Quality of Life Among People Living with HIV in Brazil.AIDS and behavior · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo understand the effects of frailty, geriatric syndromes, and comorbidity on quality of life and mortality in older adults with HIV (OAWH).
methodsCross-sectional study of the FUNCFRAIL multicenter cohort. The setting was outpatient HIV-Clinic. OAWH, 50 year or over were included. We recorded sociodemographic data, HIV infection-related data, comorbidity, frailty, geriatric syndromes (depression, cognitive impairment, falls and malnutrition), quality of life (QOL) and the estimated risk of all-cause 5-year mortality by VACS Index. Association of frailty with geriatric syndromes and comorbidity was evaluated using the Cochran-Mantel-Haenszel test.
resultsSeven hundred ninety six patients were included. 24.7% were women, mean age was 58.2 (6.3). 14.7% were 65 or over. 517 (65%) patients had ≥3 comorbidities, ≥ 1 geriatric syndrome and/or frailty. There were significant differences in the estimated risk of mortality [(frailty 10.8%) vs. (≥ 3 comorbidities 8.2%) vs. (≥ 1 geriatric syndrome 8.2%) vs. (nothing 6.2%); p = 0.01] and in the prevalence of fair or poor QOL [(frailty 71.7%) vs. (≥ 3 comorbidities 52%) vs. (≥ 1 geriatric syndrome 58.4%) vs. (nothing 51%); p = 0.01]. Cognitive impairment was significantly associated to mortality (8.7% vs. 6.2%; p = 0.02) and depression to poor QOL [76.5% vs. 50%; p = 0.01].
conclusionsFrailty, geriatric syndromes, and comorbidity had negative effects on mortality and QOL, but frailty had the greatest negative effect out of the three factors. Our results should be a wake-up call to standardize the screening for frailty and geriatric syndromes in OAWH in the clinical practice.
trial registrationNCT03558438.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.