Evidence map›Paper›PMID 36596981›Full record

SynthesisJournal of racial and ethnic health disparities2024

Differential Profile of Primary and Recurrent Ameloblastomas Among Afro-descendants and Non-Afro-descendants-a Systematic Review.

Parth Patel, Olajumoke A Effiom, Abdul-Warith O Akinshipo, Sunday O Akintoye

Open access · greenAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of racial and ethnic health disparities, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Observational
  6. Article
  7. Comparison of diagnostic methods for detection of BRAFV600E mutation in ameloblastoma.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2024
    Article
  8. Current concepts in targeted therapies for benign tumors of the jaw - A review of the literature.Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Parth PatelDornsife School of Public Health, Drexel University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8105-0031
Olajumoke A EffiomDepartment of Oral and Maxillofacial Pathology/Biology Faculty of Dental Sciences, University of Lagos, Lagos, Nigeria.ORCID http://orcid.org/0000-0001-8678-4966
Abdul-Warith O AkinshipoDepartment of Oral and Maxillofacial Pathology/Biology Faculty of Dental Sciences, University of Lagos, Lagos, Nigeria.ORCID http://orcid.org/0000-0002-1182-107X
Sunday O AkintoyeDepartment of Oral and Maxillofacial Pathology/Biology Faculty of Dental Sciences, University of Lagos, Lagos, Nigeria. akintoye@upenn.edu.ORCID http://orcid.org/0000-0002-3090-1374
University of Lagos · NGDrexel University · US

Funding

Biological Indicators of Racial Disparity in Ameloblastoma RecurrenceR01CA259307 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Sunday O Akintoye · 2022 to 2026
$1.8M
NCI NIH HHS R01 CA259307NIH HHS R01CA259307
6 · The paper itself

Abstract

Ameloblastoma is an aggressively growing jaw tumor with high recurrent properties. Reports on global and racial distribution of ameloblastoma are variable and inconclusive. The role of race and ethnicity on ameloblastoma growth characteristics, genetic mutational profile, and recurrence is also still unclear. The primary aim of this systematic review was to assess genetic, racial, and ethnic distribution of primary and recurrent ameloblastoma from published literature. The secondary aim was to assess potential correlations between ethnicity, genetic mutation, and disparities in ameloblastoma treatment outcomes in Afro-descendants and non-Afro-descendants. Twenty-three eligible articles were selected based on preferred reporting items for systematic review and meta-analysis (PRISMA), and a total of 169 ameloblastoma cases were evaluated. Data on patient demographics, ameloblastoma growth characteristics, and genetic status were collected for quantitative analysis. Among a total of 169 ameloblastoma cases, Afro-descendant patients had higher primary and recurrent ameloblastomas at 15.5% and 4.7% respectively compared to non-Afro-descendant at 10.7% and 1.8% respectively. Additionally, BRAF V600E was positively associated with 48.8% of all ameloblastomas and strong predilection for Afro-descendants. Despite the paucity of information on genetic profile of ameloblastomas in the Afro-descendant patient cohort, this ethnic group still accounted for 2.95% of all BRAF V600E-positive tumors. These suggest that Afro-descendants are understudied regarding ameloblastoma characteristics, genetic profile, and recurrence profile. Mutational analysis of ameloblastoma tumors in Afro-descendants should be promoted.

Indexed as

AmeloblastomaJaw NeoplasmsHumansMutationProto-Oncogene Proteins B-rafTreatment OutcomeProto-Oncogene Proteins B-rafAmeloblastomaEthnicityGene mutationRaceRecurrence

Identifiers

PMID36596981
PMCPMC10437082
OpenAlexW4313488992

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.