Evidence map›Paper›PMID 36596943›Full record

SynthesisPediatric research2023

Systematic review and meta-analysis of neonatal outcomes of COVID-19 vaccination in pregnancy.

Dingning Zhang, Tingting Huang, Zhihui Chen, Lulu Zhang, Qi Gao, Ge Liu, Jun Zheng, Fangrui Ding

Open access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dingning Zhang *Department of Neonatology, Tianjin Central Hospital of Obstetrics and Gynecology, 300000, Tianjin, China.
Tingting Huang *Department of Neonatology, Tianjin Central Hospital of Obstetrics and Gynecology, 300000, Tianjin, China.
Zhihui ChenDepartment of Neonatology, Tianjin Central Hospital of Obstetrics and Gynecology, 300000, Tianjin, China.
Lulu ZhangDepartment of Neonatology, Tianjin Central Hospital of Obstetrics and Gynecology, 300000, Tianjin, China.
Qi GaoDepartment of Neonatology, Tianjin Central Hospital of Obstetrics and Gynecology, 300000, Tianjin, China.
Ge LiuDepartment of Neonatology, Tianjin Central Hospital of Obstetrics and Gynecology, 300000, Tianjin, China.
Jun ZhengDepartment of Neonatology, Tianjin Central Hospital of Obstetrics and Gynecology, 300000, Tianjin, China. zhengjunpaper@126.com.
Fangrui DingDepartment of Neonatology, Tianjin Central Hospital of Obstetrics and Gynecology, 300000, Tianjin, China. youngbear@126.com.
Nankai University · CNTianjin Central Hospital of Gynecology Obstetrics · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe safety of coronavirus disease 2019 (COVID-19) vaccines during pregnancy is a particular concern. Here, we addressed the neonatal outcomes after maternal vaccination of COVID-19 during pregnancy.

methodsWe systematically searched PubMed, EMBASE, and the WHO COVID-19 Database for studies on neonatal outcomes after maternal COVID-19 vaccination from inception to 3 July 2022. Main neonatal outcomes were related to preterm, small for gestation (SGA), NICU admission, low Apgar score at 5 min (<7), and additional neonatal outcomes such as gestation <34 weeks, low birth weight and some neonatal morbidity were all also analyzed.

resultsA total of 15 studies were included. We found that maternal vaccination during pregnancy was related to the reduction rates of Preterm, SGA, Low Apgar score at 5 min (<7). In addition, there was no evidence of a higher risk of adverse neonatal outcomes after maternal vaccination of COVID-19 during pregnancy, including NICU admission, preterm birth with gestation <34 weeks, low birth weight, very low birth weight, congenital anomalies, and so on.

conclusionsCOVID-19 vaccination in pregnant women does not raise significant adverse effects on neonatal outcomes and is related to a protective effect on some neonatal outcomes. IMPACT: Present study has addressed the neonatal outcomes after maternal vaccination of COVID-19 during pregnancy. COVID-19 vaccination in pregnant women does not raise significant adverse effects on neonatal outcomes and is related to a protective effect on some neonatal outcomes. The present study could encourage pregnant women to be vaccinated against COVID-19.

Indexed as

COVID-19COVID-19 VaccinesPremature BirthFemaleHumansInfant, Low Birth WeightInfant, NewbornPregnancyPregnancy OutcomeVaccinationCOVID-19 Vaccines

Identifiers

PMID36596943
PMCPMC9808682
OpenAlexW4313489171

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.