Evidence map›Paper›PMID 36596896›Full record

ReviewNature immunology2023

T

Alexandra Schnell, Dan R Littman, Vijay K Kuchroo

Open access · greenAbstract readReview
In one paragraph

Review in Nature immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 171 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
171citing papers in PubMed, 1 pooled it
39.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

171 citing papers in PubMed, 1 synthesis or guideline pooled it, 237 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Putative mechanisms of ocular inflammation in syphilis.Journal of ophthalmic inflammation and infection · 2026
    Review
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  6. Article
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  15. Biochemistry · 2026
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

111 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alexandra SchnellEvergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3442-7750
Dan R LittmanDepartment of Cell Biology and Regenerative Medicine, New York University School of Medicine, New York, NY, USA. Dan.Littman@nyulangone.org.
Vijay K KuchrooEvergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. vkuchroo@rics.bwh.harvard.edu.ORCID http://orcid.org/0000-0001-7177-2110
Broad Institute · USHoward Hughes Medical Institute · US

Funding

Role of Negative Costimulation in Regulation of AutoimmunityP01AI039671 · NIAID · YALE UNIVERSITY · PI David A. Hafler · 1996 to 2026
$51.7M
Transgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BLAZAR, BRUCE R · 2003 to 2023
$42.5M
Transgenic / Knock-out mouse coreP01AI073748 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BEHAR, SAMUEL M · 2008 to 2019
$17.1M
Role of Th1 specific cell surface molecule Tim-3 in EAE.R01NS045937 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI KUCHROO, VIJAY K. · 2003 to 2016
$4.9M
T CELL RESPONSE TO MYELIN PROTEOLIPID PROTEINR01NS030843 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI KUCHROO, VIJAY K. · 1998 to 2019
$4.1M
Determinants of induced Treg and inflammatory Th17 cell balance in response to potentially pathogenic microbiotaR01AI158687 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Dan Littman · 2021 to 2026
$3.2M
Role of Tim-3:Bat-3 pathway in inducing tolerogenic DCs and peripheral toleranceR01AI144166 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI VIJAY K. KUCHROO · 2020 to 2026
$3.2M
Mechanism of microbiota-mediated potentiation of checkpoint blockade efficacy in lung cancerR01CA255635 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LITTMAN, DAN · 2021 to 2025
$2.8M
NCI NIH HHS R01 CA255635NIAID NIH HHS P01 AI039671NIAID NIH HHS P01 AI056299NIAID NIH HHS P01 AI073748NIAID NIH HHS R01 AI144166NIAID NIH HHS R01 AI158687NINDS NIH HHS R01 NS030843NINDS NIH HHS R01 NS045937
6 · The paper itself

Abstract

Since their discovery almost two decades ago, interleukin-17-producing CD4

Indexed as

InflammationTh17 CellsAnimalsCell PlasticityDisease Models, AnimalMiceT-Lymphocyte Subsets

Identifiers

PMID36596896
PMCPMC10795475
OpenAlexW4313528847

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.