ArticlePediatric radiology2023
Pilot study to determine whether reduced-dose photon-counting detector chest computed tomography can reliably display Brody II score imaging findings for children with cystic fibrosis at radiation doses that approximate radiographs.
Article in Pediatric radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Radiation dose and objective image quality of photon-counting detector computed tomography in pediatric imaging: a systematic review and meta-analysis.Pediatric radiology · 2026Pooled it
- Next-gen paediatric imaging: ultra-low dose chest photon-counting CT approaching chest radiograph doses.European radiology experimental · 2026Article
- Photon-counting detector computed tomography in thoracic oncology: revolutionizing tumor imaging through precision and detail.Diagnostic and interventional radiology (Ankara, Turkey) · 2026Review
- CT Radiation Dose Reduction With Preserved Diagnostic Performance: How Far Have We Come Over 25 Years?AJR. American journal of roentgenology · 2026Review
- Clinical outcomes of sub-millisievert CT evaluation of congenital chest wall deformity using photon counting CT: a new standard of care?Research square · 2026Article
- High performance of low/ultralow-dose photon-counting CT for pulmonary metastasis in young musculoskeletal malignancy patients.European journal of radiology open · 2025Article
- Pediatric photon-counting chest CT enables iodinated contrast dose reduction with preserved image quality.Pediatric radiology · 2025Observational
- Ultralow dose computed tomography as an alternative to conventional chest radiography for the evaluation of disease severity in paediatric cystic fibrosis.Scientific reports · 2025Article
- A New Simple to Use Chest CT Scoring System: Validation Study.Pediatric pulmonology · 2025Article
- Photon-counting CT yields superior abdominopelvic image quality at lower radiation and iodinated contrast doses.Pediatric radiology · 2025Article
- Pediatric contrast-enhanced chest CT on a photon-counting detector CT: radiation dose and image quality compared to energy-integrated detector CT.Pediatric radiology · 2024Observational
- Low-dose high-resolution chest CT in adults with cystic fibrosis: intraindividual comparison between photon-counting and energy-integrating detector CT.European radiology experimental · 2024Article
- Photon counting detector computed tomography in pediatric cardiothoracic CT imaging.Radiology advances · 2024Review
- Task-based automatic keV selection: leveraging routine virtual monoenergetic imaging for dose reduction on clinical photon-counting detector CTPhysics in medicine and biology · 2024Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Brody II score uses chest CT to guide therapeutic changes in children with cystic fibrosis; however, patients and providers are often reticent to undergo chest CT given concerns about radiation.
objectiveWe sought to determine the ability of a reduced-dose photon-counting detector (PCD) chest CT protocol to reproducibly display pulmonary disease severity using the Brody II score for children with cystic fibrosis (CF) scanned at radiation doses similar to those of a chest radiograph. MATERIALS AND
methodsPediatric patients with CF underwent non-contrast reduced-dose chest PCD-CT. Volumetric inspiratory and expiratory scans were obtained without sedation or anesthesia. Three pediatric radiologists with Certificates of Added Qualification scored each scan on an ordinal scale and assigned a Brody II score to grade bronchiectasis, peribronchial thickening, parenchymal opacity, air trapping and mucus plugging. We report image-quality metrics using descriptive statistics. To calculate inter-rater agreement for Brody II scoring, we used the Krippendorff alpha and intraclass correlation coefficient (ICC).
resultsFifteen children with CF underwent reduced-dose PCD chest CT in both inspiration and expiration (mean age 8.9 years, range, 2.5-17.5 years; 4 girls). Mean volumetric CT dose index (CTDI
conclusionReduced-dose PCD-CT permits diagnostic image quality and reproducible identification of Brody II scoring imaging findings at radiation doses similar to those for chest radiography.
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