ArticleNature communications2023
Vertebrate OTOP1 is also an alkali-activated channel.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Decay chemicals activate a pH-sensing pathway to initiate a persistent state.bioRxiv : the preprint server for biology · 2026Article
- Human OTOP3 requires strong acidification for activation and exhibits mixed proton-anion permeation.The Journal of biological chemistry · 2026Article
- Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface.Nature communications · 2025Article
- Preferential allosteric modulation of Otop1 channels by small molecule compounds.Communications biology · 2025Article
- Genetic analysis of non-syndromic peg lateralis using whole-exome sequencing.Frontiers in genetics · 2025Article
- Article
- Gating elements for carvacrol activation of the OTOP1 proton channel.Communications biology · 2024Article
- Avoiding alkaline taste through ionotropic receptors.iScience · 2024Article
- Transcendent Aspects of Proton Channels.Annual review of physiology · 2024Review
- The taste for health: the role of taste receptors and their ligands in the complex food/health relationship.Frontiers in nutrition · 2024Article
- Tastant-receptor interactions: insights from the fruit fly.Frontiers in nutrition · 2024Review
- Acid and Alkali Taste Sensation.Metabolites · 2023Review
- The proton channel OTOP1 is a sensor for the taste of ammonium chloride.Nature communications · 2023Article
- A new polymodal gating model of the proton-activated chloride channel.PLoS biology · 2023Article
- Zinc activation of OTOP proton channels identifies structural elements of the gating apparatus.eLife · 2023Article
- The avian taste system.Frontiers in physiology · 2023Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although alkaline sensation is critical for survival, alkali-activated receptors are yet to be identified in vertebrates. Here, we showed that the OTOP1 channel can be directly activated by extracellular alkali. Notably, OTOP1 biphasically mediated proton influx and efflux with extracellular acid and base stimulation, respectively. Mutations of K221 and R554 at the S5-S6 and S11-S12 linkers significantly reduced alkali affinity without affecting acid activation, suggesting that different domains are responsible for acid- and alkali-activation of OTOP1. The selectivity for H
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.