Evidence map›Paper›PMID 36596589›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Altered regional homogeneity and its association with cognitive function in adolescents with borderline personality disorder.

Xiaoping Yi, Yan Fu, Zhejia Zhang, Furong Jiang, Qian Xiao, Bihong T Chen

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Xiaoping YiFrom the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Yi, Fu); the National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Changsha, Hunan, P.R. China (Yi, Fu); the National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Yi); the Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Zhang); the Mental Health Center of Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Jiang, Xiao); the Department of Diagnostic Radiology, City of Hope National Medical Center, Duarte, Calif., USA (Chen).
Yan FuFrom the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Yi, Fu); the National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Changsha, Hunan, P.R. China (Yi, Fu); the National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Yi); the Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Zhang); the Mental Health Center of Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Jiang, Xiao); the Department of Diagnostic Radiology, City of Hope National Medical Center, Duarte, Calif., USA (Chen).
Zhejia ZhangFrom the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Yi, Fu); the National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Changsha, Hunan, P.R. China (Yi, Fu); the National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Yi); the Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Zhang); the Mental Health Center of Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Jiang, Xiao); the Department of Diagnostic Radiology, City of Hope National Medical Center, Duarte, Calif., USA (Chen).
Furong JiangFrom the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Yi, Fu); the National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Changsha, Hunan, P.R. China (Yi, Fu); the National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Yi); the Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Zhang); the Mental Health Center of Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Jiang, Xiao); the Department of Diagnostic Radiology, City of Hope National Medical Center, Duarte, Calif., USA (Chen).
Qian XiaoFrom the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Yi, Fu); the National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Changsha, Hunan, P.R. China (Yi, Fu); the National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Yi); the Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Zhang); the Mental Health Center of Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Jiang, Xiao); the Department of Diagnostic Radiology, City of Hope National Medical Center, Duarte, Calif., USA (Chen) xiaoqian851112@126.com.
Bihong T ChenFrom the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Yi, Fu); the National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Changsha, Hunan, P.R. China (Yi, Fu); the National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Yi); the Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Zhang); the Mental Health Center of Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (Jiang, Xiao); the Department of Diagnostic Radiology, City of Hope National Medical Center, Duarte, Calif., USA (Chen).
Xiangya Hospital Central South University · CNCentral South University · CNCity Of Hope National Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdolescents with borderline personality disorder often have cognitive impairment, but the underlying mechanism for this is not clear. This study was aimed at assessing alterations in regional homogeneity using resting-state functional MRI (fMRI) in adolescents with borderline personality disorder, and evaluating the associations between regional homogeneity and cognitive testing scores.

methodsWe enrolled 50 adolescents with borderline personality disorder (age 12-17 years) and 21 age- and sex-matched healthy controls. We performed regional homogeneity and seed-based functional connectivity analysis for both groups. We also performed correlative analysis for regional homogeneity and cognitive testing scores.

resultsCompared with healthy controls, adolescents with borderline personality disorder had reduced regional homogeneity values in the frontal cortex (including the left inferior orbitofrontal cortex and the bilateral superior frontal cortex) as well as in the left precuneus in the default mode network. Adolescents with borderline personality disorder also had higher regional homogeneity values in several cortical regions: the right middle temporal gyrus, the right cuneus, the right precentral gyrus and the left middle occipital gyrus. Regional homogeneity values in the left middle occipital gyrus, left inferior orbitofrontal cortex and right superior frontal gyrus were associated with cognitive testing scores in adolescents with borderline personality disorder. We also found increased functional connectivity between the left middle occipital gyrus and right superior frontal gyrus in adolescents with borderline personality disorder. LIMITATIONS: This study had a modest sample size, with a possible case selection bias for patients with more severe illness. This cohort also included patients with comorbidities or taking psychotropic medications, which may have confounded study results.

conclusionAlterations in regional homogeneity and functional connectivity in brain regions that involve the limbic-cortical circuit could be neural correlates for cognitive impairment in adolescents with borderline personality disorder.

Indexed as

Borderline Personality DisorderMotor CortexAdolescentBrainChildCognitionHumansMagnetic Resonance Imaging

Identifiers

PMID36596589
PMCPMC9829058
OpenAlexW4313523145

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.