ArticleEmerging infectious diseases2023
Circovirus Hepatitis Infection in Heart-Lung Transplant Patient, France.
Article in Emerging infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Hijacking of host PCNA by circovirus replication-associated protein to recruit POLD1 drives viral DNA replication and is inhibited by R428.PLoS pathogens · 2026Article
- Review
- "Innovative diagnostics and treatments of infections in transplantation," report from the 2025Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Identification and biochemical characterization of a novel porcine circovirus associated with porcine respiratory and diarrheal diseases.Microbiology spectrum · 2025Article
- Surveillance and prevention of infection in clinical xenotransplantation.Clinical microbiology reviews · 2025Review
- A duplex HiFi-LAMP assay for screening of two novel human circoviruses HCirV-1 and HCirV-2.BMC infectious diseases · 2024Article
- Human Circovirus in Patients with Hepatitis, Hong Kong.Emerging infectious diseases · 2024Article
- Circovirus Hepatitis in Immunocompromised Patient, Switzerland.Emerging infectious diseases · 2024Article
- 2024 taxonomy update for the family Circoviridae.Archives of virology · 2024Review
- Article
- Application of metagenomic next-generation sequencing in the diagnosis of infectious diseases.Frontiers in cellular and infection microbiology · 2024Review
- Intra- and inter-host origin, evolution dynamics and spatial-temporal transmission characteristics of circoviruses.Frontiers in immunology · 2024Article
- Novel cycloviruses identified by mining human blood metagenomic data show close relationship to those from animals.Frontiers in microbiology · 2024Article
- The International Virus Bioinformatics Meeting 2023.Viruses · 2023Article
- Article
- Article
- Next-Generation Sequencing for Identifying Unknown Pathogens in Sentinel Immunocompromised Hosts.Emerging infectious diseases · 2023Article
Corrections and comments
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Authors and funding
17 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In March 2022, a 61-year-old woman in France who had received a heart-lung transplant sought treatment with chronic hepatitis mainly characterized by increased liver enzymes. After ruling out common etiologies, we used metagenomic next-generation sequencing to analyze a liver biopsy sample and identified an unknown species of circovirus, tentatively named human circovirus 1 (HCirV-1). We found no other viral or bacterial sequences. HCirV-1 shared 70% amino acid identity with the closest known viral sequences. The viral genome was undetectable in blood samples from 2017-2019, then became detectable at low levels in September 2020 and peaked at very high titers (10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.